Viral Fusion Mechanisms presents the first comprehensive review on this exciting topic. The book focuses on molecular mechanisms rather than phenomonology and examines a wide range of viruses, including influenza, HIV, Sendai, SFV, Vaccinia, VSV, and RSV. Recent theoretical work on dissecting protein-mediated membrane fusion is discussed, and the most promising new technologies for elucidating mechanisms are highlighted.
Viral Fusion Mechanisms is an essential reference for biophysicists, cell biologists, colloid chemists, immunologists, microbiologists, molecular biologists, and virologists.
Table of Contents
Growth and Assay of Viruses (L.A. Benadi). Cryo-Electron Microscopy (F. Booy). Peptide-Bilayer Interactions: Physical Measurement Related to Peptide Structure (J.D. Lear and M. Rafalski). Fusion-Protein Membrane Interactions as Studied by Hydrophobic Photolabelling (J. Brunner and M. Tsurudome). Influenza Virus Fusion: From Models Toward a Mechanism (T. Stegmann and A. Helenius). Towards a Dissection of the Influenza Hemagglutinin Mediated Membrane Fusion Pathway (M. Clague, C. Schoch and R. Blumenthal). The Influenza Virus Hemagglutinin: Membrane Fusion Activity in Whole Virions and Reconstituted Virosomes (J. Wilschut and Romke Bron). Architecture of the Influenza Hemagglutinin Membrane Fusion Site (J. Bentz, H. Ellens and D. Alford). Membrane Fusion Induced by Herpes Simplex Virus (P. Spear). The HIV-Cell Fusion Reaction (J. Moore, B. Jameson, R. Weiss, and Q. Sattentau). CD4-Induced Change in gp120/41 Conformation and its Potential Relationship to Fusion (H. Ellens and C. Larsen). The Fusion of Sendai Virus (P. Yeagle). Role of Viral Glycoprotein Mobility in Sendai Virus-Mediated Cell Fusion (Y. Henis). Respiratory Syncytial Virus Interactions with Host Cell Membranes: An Enigma Among the Paramyxoviridae (A. Walter and L.A. Downing). Membrane Fusion Activity of Alphaviruses (M. Kielian). Membrane Fusion Activity of Vaccinia Virus (R. Blasco and R.W. Doms). Vesicular Stomatitis Virus Fusion (J. Lenard). Kinetics and Extent of Virus-Cell Aggregation and Fusion (S. Nir, M. Pedroso de Lima, C. Larsen, J. Wilschut, D. Hoekstra, and N. Düzgünes). Membrane Fusion Intermediates and the Kinetics of Membrane Fusion (J. Bentz). Thermodynamics of Fusion Intermediates (D. Siegel).