Targeted Delivery of Small and Macromolecular Drugs

Ajit S. Narang, Ram I. Mahato

July 26, 2017 by CRC Press
Reference - 630 Pages - 185 B/W Illustrations
ISBN 9781138114517 - CAT# K35352

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  • Provides an overview of principles and current status of leading approaches
  • Focuses on challenges, novel ideas, competing technologies, bottlenecks, and strategies that have been successful in the past
  • Presents detailed background of the development of successfully marketed products
  • Illustrates synergistic application of advancements in different basic sciences toward improving drug targeting platforms


Site-specific drug delivery and targeting attracts much research interest from both academia and industry, but because of the many challenges faced in the development of these systems, only a handful of targeted therapies have successfully made it into clinical practice.

Focusing on the delivery technologies that utilize both systemic and local routes of administration, Targeted Delivery of Small and Macromolecular Drugs brings together field experts who summarize current progress and discuss novel ideas currently being explored to overcome these challenges.

The contributors discuss the most promising strategies for drug targeting and also examine targeted drug delivery platforms and technologies at various stages of clinical and preclinical development, including:

    • Active targeting
    • Nucleic acid delivery and targeting
    • Intracellular/organelle-specific strategies
    • Prodrug strategies
    • Organ or tissue-specific drug delivery
    • Drug-polymer conjugates and micelles
    • Stimuli-responsive systems

The book demonstrates why targeted delivery is one of the most exciting contributions pharmaceutical sciences can make to drug therapy.


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