Pharmaceutical Science

Drug Development

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Quantitative Structure – Activity Relationship: A Practical Approach

Siavoush Dastmalchi, Maryam Hamzeh-Mivehroud, Babak Sokouti
May 08, 2018

Generally speaking, quantitative-structure activity relationship (QSAR) is a technique which correlates the biological activities of a set of compounds to their structures using a mathematical equation represented in its general form by Biological Activity = f (x1, ..., xn), where f is a...

3D Cell Culture: Fundamentals and Applications in Tissue Engineering and Regenerative Medicine

Ranjna C. Dutta, Aroop K. Dutta
April 30, 2018

3D cell culture is yet to be adopted and exploited to its full potential. It promises to upgrade and bring our understanding about human physiology to the highest level with the scope of applying the knowledge for better diagnosis as well as therapeutics. The focus of this book is on the direct...

Water-Insoluble Drug Formulation, Third Edition

Ron Liu
March 16, 2018

Properties and Formulation: From Theory to Real-World Application Scientists have attributed more than 40 percent of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility. Issues surrounding water insolubility can postpone or completely derail...

Handbook of Pharmaceutical Manufacturing Formulations: Volume Three, Liquid Products

Sarfaraz K. Niazi
February 26, 2018

While liquid drugs do not share the compression problems of solid dosage forms, the filling problems of powder dosage forms, or the consistency problems of semisolid dosage forms, they do have their own set of considerations in the formulation and manufacturing stages. Highlights from Liquid...

Pharmaceutical Dosage Forms: Capsules

Larry L. Augsburger, Stephen W. Hoag
November 09, 2017

Pharmaceutical Dosage Forms: Capsules covers the development, composition, and manufacture of capsules. Despite the important role that capsules play in drug delivery and product development, few comprehensive texts on the science and technology of capsules have been available for the research and...

Toxicologic Pathology: Nonclinical Safety Assessment

Pritam S. Sahota, James A. Popp, Jerry F. Hardisty, Chirukandath Gopinath
October 23, 2017

As drug development shifts over time to address unmet medical needs and more targeted therapies are developed, previously unseen pharmacological or off-target effects may occur in treatment. Designed to provide practical information for the bench toxicologic pathologist working in pharmaceutical...

Principles of Animal Extrapolation (1991)

Edward J. Calabrese
September 20, 2017

Principles of Animal Extrapolation addresses the conceptual basis for animal extrapolation and provides an abundance of documentation that illustrates how these principles may be applied in the selection of the more appropriate models and in the interpretation of toxicological studies. The book...

Respiratory Drug Delivery (1989)

Peter R. Byron
September 20, 2017

The focus of this book is on subjects related to drug delivery to the lung. The text spans topics from aerosol deposition through pharmaceutical chemistry and formulation to the final clinical evaluation of pharmaceutical products. Utilizing a multi-disciplinary approach, the chapters consider...

Cancer Vaccines: From Research to Clinical Practice

Adrian Bot, Mihail Obrocea, Francesco M. Marincola
September 11, 2017

Recent advances in immunology and biology have opened new horizons in cancer therapy, included in the expanding array of cancer treatment options, which are immunotherapies, or cancer vaccines, for both solid and blood borne cancers. Cancer Vaccines: From Research to Clinical Practice is the first...

Targeted Delivery of Small and Macromolecular Drugs

Ajit S. Narang, Ram I. Mahato
July 26, 2017

Site-specific drug delivery and targeting attracts much research interest from both academia and industry, but because of the many challenges faced in the development of these systems, only a handful of targeted therapies have successfully made it into clinical practice. Focusing on the delivery...

New Generation Vaccines, Fourth Edition

Myrone M. Levine, Myron M. Levine, Gordon Dougan, Michael F. Good, Margaret A. Liu, Gary J. Nabel, James P. Nataro, Rino Rappuoli
July 13, 2017

Highlighting the latest activities and initiatives of prominent organizations working in the vaccine industry such as the Bill and Melinda Gates Foundation, The Global Alliance for Vaccines and Immunization, WHO, UNICEF, the World Bank, New Generation Vaccines, Fourth Edition, details steps...

Delivery Strategies for Antisense Oligonucleotide Therapeutics

Saghir Akhtar
July 13, 2017

With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids. Important delivery issues, such as improving biological stability, improving cell-specific...

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