Statistical Analysis of Gene Expression Microarray Data

1st Edition

Terry Speed

Chapman and Hall/CRC
Published March 26, 2003
Textbook - 240 Pages - 48 Color & 99 B/W Illustrations
ISBN 9781584883272 - CAT# C3278
Series: Chapman & Hall/CRC Interdisciplinary Statistics

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Features

  • Provides the first comprehensive coverage by statisticians of the issues, features, and problems associated with the analysis of microarray data
  • Presents contributions from the pre-eminent statisticians working in the field
  • Offers a presentation accessible to biologists, geneticists, and computer scientists as well as statisticians
  • Covers the most important topics needed for the analysis of microarray data - pre-processing issues, experiment design, classification, and clustering
  • Summary

    Although less than a decade old, the field of microarray data analysis is now thriving and growing at a remarkable pace. Biologists, geneticists, and computer scientists as well as statisticians all need an accessible, systematic treatment of the techniques used for analyzing the vast amounts of data generated by large-scale gene expression studies. And there is arguably no group better qualified to do so than the authors of this book.

    Statistical Analysis of Gene Expression Microarray Data promises to become the definitive basic reference in the field. Under the editorship of Terry Speed, some of the world's most pre-eminent authorities have joined forces to present the tools, features, and problems associated with the analysis of genetic microarray data. These include::

  • Model-based analysis of oligonucleotide arrays, including expression index computation, outlier detection, and standard error applications
  • Design and analysis of comparative experiments involving microarrays, with focus on \ two-color cDNA or long oligonucleotide arrays on glass slides
  • Classification issues, including the statistical foundations of classification and an overview of different classifiers
  • Clustering, partitioning, and hierarchical methods of analysis, including techniques related to principal components and singular value decomposition

    Although the technologies used in large-scale, high throughput assays will continue to evolve, statistical analysis will remain a cornerstone of their success and future development. Statistical Analysis of Gene Expression Microarray Data will help you meet the challenges of large, complex datasets and contribute to new methodological and computational advances.
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