Statistical Genetics & Bioinformatics

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Statistical Modeling and Machine Learning for Molecular Biology

Alan Moses
January 04, 2017

Molecular biologists are performing increasingly large and complicated experiments, but often have little background in data analysis. The book is devoted to teaching the statistical and computational techniques molecular biologists need to analyze their data. It explains the big-picture concepts...

Applied Surrogate Endpoint Evaluation Methods with SAS and R

Ariel Alonso, Theophile Bigirumurame, Tomasz Burzykowski, Marc Buyse, Geert Molenberghs, Leacky Muchene, Nolen Joy Perualila, Ziv Shkedy, Wim Van der Elst
December 08, 2016

An important factor that affects the duration, complexity and cost of a clinical trial is the endpoint used to study the treatment’s efficacy. When a true endpoint is difficult to use because of such factors as long follow-up times or prohibitive cost, it is sometimes possible to use a surrogate...

Applied Biclustering Methods for Big and High-Dimensional Data Using R

Adetayo Kasim, Ziv Shkedy, Sebastian Kaiser, Sepp Hochreiter, Willem Talloen
October 04, 2016

Proven Methods for Big Data Analysis As big data has become standard in many application areas, challenges have arisen related to methodology and software development, including how to discover meaningful patterns in the vast amounts of data. Addressing these problems, Applied Biclustering...

Mixture Model-Based Classification

Paul D. McNicholas
August 19, 2016

"This is a great overview of the field of model-based clustering and classification by one of its leading developers. McNicholas provides a resource that I am certain will be used by researchers in statistics and related disciplines for quite some time. The discussion of mixtures with heavy tails...

Crop Breeding: Bioinformatics and Preparing for Climate Change

Santosh Kumar
July 15, 2016

This title includes a number of Open Access chapters. Climate change will severely impact the world’s food supply unless steps are taken to increase crop resilience. Otherwise, the negative effects on both the yield and the quality of crop plants are predicted to be immense. Plant genomics is a...

Understanding Enzymes: Function, Design, Engineering, and Analysis

Allan Svendsen
May 17, 2016

Understanding Enzymes: Function, Design, Engineering, and Analysis focuses on the understanding of enzyme function and optimization gained in the past decade, past enzyme function analysis, enzyme engineering, and growing insights from the simulation work and nanotechnology measurement of enzymes...

Gene-Environment Interaction Analysis: Methods in Bioinformatics and Computational Biology

Sumiko Anno
April 06, 2016

Gene–environment (G × E) interaction analysis is a statistical method for clarifying G × E interactions applicable to a phenotype or a disease that is the result of interactions between genes and the environment. This book is the first to deal with the theme of G × E interaction analysis. It...

Next-Generation Sequencing Data Analysis

Xinkun Wang
February 24, 2016

A Practical Guide to the Highly Dynamic Area of Massively Parallel Sequencing The development of genome and transcriptome sequencing technologies has led to a paradigm shift in life science research and disease diagnosis and prevention. Scientists are now able to see how human diseases and...

Big Data Analysis for Bioinformatics and Biomedical Discoveries

Shui Qing Ye
December 22, 2015

Demystifies Biomedical and Biological Big Data Analyses Big Data Analysis for Bioinformatics and Biomedical Discoveries provides a practical guide to the nuts and bolts of Big Data, enabling you to quickly and effectively harness the power of Big Data to make groundbreaking biological discoveries,...

Semialgebraic Statistics and Latent Tree Models

Piotr Zwiernik
August 21, 2015

Semialgebraic Statistics and Latent Tree Models explains how to analyze statistical models with hidden (latent) variables. It takes a systematic, geometric approach to studying the semialgebraic structure of latent tree models. The first part of the book gives a general introduction to key...

Reproducible Research with R and R Studio, Second Edition

Christopher Gandrud
June 11, 2015

All the Tools for Gathering and Analyzing Data and Presenting Results Reproducible Research with R and RStudio, Second Edition brings together the skills and tools needed for doing and presenting computational research. Using straightforward examples, the book takes you through an entire...

Advanced R

Hadley Wickham
September 25, 2014

An Essential Reference for Intermediate and Advanced R Programmers Advanced R presents useful tools and techniques for attacking many types of R programming problems, helping you avoid mistakes and dead ends. With more than ten years of experience programming in R, the author illustrates the...