One of the most important organisms in biotechnology, Corynebacterium glutamicum is currently used to produce 2 million tons of amino acids per year for a rapidly expanding market. Until now, research and information have been scattered among individual papers which are often difficult to locate in a timely manner.
As the first complete compilation of major findings, Handbook of Corynebacterium glutamicum is a comprehensive source of scientific and technical information required for the understanding and manipulation of C. glutamicum. The book summarizes the current knowledge in the field ofC. glutamicum research from its discovery in 1957 through the most recent studies at the genomic and systemic level, and provides a basis for future work. Written by experts from industry and academia, chapters cover all major aspects of C. glutamicum, including physiology, biochemistry, genetics, and industrial applications.
Just as C. glutamicum has proven its profitability in industry and research, this book will demonstrate its value to the scientists striving to understand and develop even more efficient producer strains of this promising microorganism.
Table of Contents
Part I: History
A Short History of the Birth of the Amino Acid Industry in Japan, S. Kinoshita
Part II: Taxonomy
Corynebacterium Taxonomy, W. Liebl
Part III: Genome, Plasmids and Gene Expression
The Genomes of Amino Acid-producing Corynebacteria, J. Kalinowski
Native Plasmids of Amino Acid-producing Corynebacteria, A. Tauch
Regulation of Gene Expression, M. Pátek
Proteomics, S. Schaffer and A. Burkovski
Part IV: Transport
The Cell Envelope of Corynebacteria, M. Daffé
Genomic Analyses of Transporter Proteins in Corynebacterium glutamicum and Corynebacterium efficiens, B. Winnen, J. Felce, and M. H. Saier, Jr.
Export of Amino Acids and Other Solutes, L. Eggeling
Part V: Physiology and Regulation
Central Metabolism: Sugar Uptake and Conversion, A. Yokota and N.D. Lindley
Central Metabolism: Tricarboxylic Acid Cycle and Anaplerotic Reactions, B. Eikmanns
Metabolic Flux Analysis in Corynebacterium glutamicum, C. Wittmann and A.A. De Graaf
Respiratory Energy Metabolism, M. Bott and A. Niebisch
Nitrogen Metabolism and Its Regulation, A. Burkovski
Sulfur Metabolism and Regulation, H.-S. Lee
Phosphorus Metabolism, V.F. Wendisch and M. Bott
Vitamin Synthesis: Carotenoids, Biotin, and Pantothenate, G. Sandmann and H. Yukawa
Osmoregulation, S. Morbach and R. Krämer
Part VI: Synthesis and Production
L-Glutamate Production, E. Kimura
L-Lysine Production, R. Kelle, T. Hermann, and B. Bathe
L-Tryptophan Production, M. Ikeda
Synthesis of L-Threonine and Branched Chain Amino Acids, L.B. Willis, P. A. Lessard, and A. J. Sinskey
Part VII: Experiments