Clinical Trials in Oncology, Third Edition

Stephanie Green, Jacqueline Benedetti, Angela Smith, John Crowley

May 9, 2012 by CRC Press
Reference - 264 Pages - 59 B/W Illustrations
ISBN 9781439814482 - CAT# K10744
Series: Chapman & Hall/CRC Interdisciplinary Statistics


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  • Includes new sections on Phase I design and array data
  • Emphasizes the importance of proper design, management, and analysis
  • Incorporates expanded discussions on competing risks, subset analyses, and randomized Phase IIs
  • Contains further comments on prognostic factor analysis
  • Clearly describes complex exploratory analysis methods


The third edition of the bestselling Clinical Trials in Oncology provides a concise, nontechnical, and thoroughly up-to-date review of methods and issues related to cancer clinical trials. The authors emphasize the importance of proper study design, analysis, and data management and identify the pitfalls inherent in these processes. In addition, the book has been restructured to have separate chapters and expanded discussions on general clinical trials issues, and issues specific to Phases I, II, and III. New sections cover innovations in Phase I designs, randomized Phase II designs, and overcoming the challenges of array data.

Although this book focuses on cancer trials, the same issues and concepts are important in any clinical setting. As always, the authors use clear, lucid prose and a multitude of real-world examples to convey the principles of successful trials without the need for a strong statistics or mathematics background. Armed with Clinical Trials in Oncology, Third Edition, clinicians and statisticians can avoid the many hazards that can jeopardize the success of a trial.

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