Statistics

Biostatistics and Epidemiology

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Handbook of Quantile Regression

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Roger Koenker, Victor Chernozhukov, Xuming He, Limin Peng
October 25, 2017

Quantile regression constitutes an ensemble of statistical techniques intended to estimate and draw inferences about conditional quantile functions. Median regression, as introduced in the 18th century by Boscovich and Laplace, is a special case. In contrast to conventional mean regression that mini...

Adaptive Survey Design

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Barry Schouten, Andy Peytchev, James Wagner
August 4, 2017

Adaptive survey designs (ASDs) provide a framework for data-driven tailoring of data collection procedures to different sample members, often for cost and bias reduction. People vary in how likely they are to respond and in how they respond. This variation leads to opportunities to selectively deplo...

Methods in Comparative Effectiveness Research

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Constantine Gatsonis, Sally C. Morton
February 7, 2017

Comparative effectiveness research (CER) is the generation and synthesis of evidence that compares the benefits and harms of alternative methods to prevent, diagnose, treat, and monitor a clinical condition or to improve the delivery of care (IOM 2009). CER is conducted to develop evidence that will...

Handbook of Methods for Designing, Monitoring, and Analyzing Dose-Finding Trials

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John O'Quigley, Alexia Iasonos, Björn Bornkamp
April 26, 2017

Handbook of Methods for Designing, Monitoring, and Analyzing Dose-Finding Trials gives a thorough presentation of state-of-the-art methods for early phase clinical trials. The methodology of clinical trials has advanced greatly over the last 20 years and, arguably, nowhere greater than that of ear...

Displaying Time Series, Spatial, and Space-Time Data with R

Oscar Perpinan Lamigueiro
August 15, 2018

Focusing on the exploration of data with visual methods, Displaying Time Series, Spatial, and Space-Time Data with R, Second Edition, presents methods and R code for producing high-quality static graphics, interactive visualizations, and animations of time series, spatial, and space-time data....

Encyclopedia of Biopharmaceutical Statistics - Four Volume Set

Shein-Chung Chow
August 13, 2018

Since the publication of the first edition in 2000, there has been an explosive growth of literature in biopharmaceutical research and development of new medicines. This encyclopedia (1) provides a comprehensive and unified presentation of designs and analyses used at different stages of the drug...

Analytical Similarity Assessment in Biosimilar Product Development

Shein-Chung Chow
August 01, 2018

This book focuses on analytical similarity assessment in biosimilar product development following the FDA’s recommended stepwise approach for obtaining totality-of-the-evidence for approval of biosimilar products. It covers concepts such as the tiered approach for assessment of similarity of...

Flexible Imputation of Missing Data, Second Edition

Stef van Buuren
July 16, 2018

Missing data pose challenges to real-life data analysis. Simple ad-hoc fixes, like deletion or mean imputation, only work under highly restrictive conditions, which are often not met in practice. Multiple imputation replaces each missing value by multiple plausible values. The variability between...

Bayesian Demographic Estimation and Forecasting

John Bryant, Junni L. Zhang
July 03, 2018

Bayesian Demographic Estimation and Forecasting presents three statistical frameworks for modern demographic estimation and forecasting. The frameworks draw on recent advances in statistical methodology to provide new tools for tackling challenges such as disaggregation, measurement error, missing...

Handbook of Statistical Methods for Case-Control Studies

Ørnulf Borgan, Norman Breslow, Nilanjan Chatterjee, Mitchell H. Gail, Alastair Scott, Chris J. Wild
July 02, 2018

Handbook of Statistical Methods for Case-Control Studies is written by leading researchers in the field. It provides an in-depth treatment of up-to-date and currently developing statistical methods for the design and analysis of case-control studies, as well as a review of classical principles and...

Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R

Jianrong Wu
June 18, 2018

Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R provides a thorough presentation of the principles of designing and monitoring cancer clinical trials in which time-to-event is the primary endpoint. Traditional cancer trial designs with...

Statistics for Biotechnology Process Development

Todd Coffey, Harry Yang
June 05, 2018

Written specifically for biotechnology scientists, engineers, and quality professionals, this book describes and demonstrates the proper application of statistical methods throughout Chemistry, Manufacturing, and Controls (CMC). Filled with case studies, examples, and easy-to-follow explanations of...

Bayesian Methods for Repeated Measures

Lyle D. Broemeling
June 01, 2018

Analyze Repeated Measures Studies Using Bayesian Techniques Going beyond standard non-Bayesian books, Bayesian Methods for Repeated Measures presents the main ideas for the analysis of repeated measures and associated designs from a Bayesian viewpoint. It describes many inferential methods for...

Bayesian Disease Mapping: Hierarchical Modeling in Spatial Epidemiology, Third Edition

Andrew B. Lawson
May 24, 2018

Since the publication of the second edition, many new Bayesian tools and methods have been developed for space-time data analysis, the predictive modeling of health outcomes, and other spatial biostatistical areas. Exploring these new developments, Bayesian Disease Mapping: Hierarchical Modeling in...

Nonparametric Models for Longitudinal Data: With Implementation in R

Colin O. Wu, Xin Tian
May 15, 2018

Nonparametric Models for Longitudinal Data with Implementations in R presents a comprehensive summary of major advances in nonparametric models and smoothing methods with longitudinal data. It covers methods, theories, and applications that are particularly useful for biomedical studies in the era...

Medical Statistics: An A-Z Companion, Second Edition

Filomena Pereira-Maxwell
May 04, 2018

This invaluable, jargon-free guide to essential medical terminology in an accessible A-Z format is ideal for medical, allied health and biomedical science students and researchers, clinicians and health care practitioners. Avoiding the complex language that is so often a feature of...

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