Phosphate in Pediatric Health and Disease provides a state-of-the-art overview of normal physiology, pathophysiology, genetics, clinical and therapeutic aspects of different types of phosphate homeostasis in early life. The book reviews the developmental physiology of phosphate metabolism from the fetus to the adolescent. It describes the pathophysiologic mechanisms associated with perturbations in phosphate homeostasis as well as discusses the different clinical conditions related to abnormal mineral metabolism, parathyroid hormone and vitamin D in infancy, childhood, and adolescence, and the modern diagnostic and therapeutic modalities. This book will benefit pediatricians, endocrinologists, neurologists, nutritionists, and researchers in the field of mineral metabolism.
Table of Contents
1. Phosphate Nutrition 2. Renal Handling of Phosphate 3. Interrelationships of Parathormone, Phosphate, and 1,25(OH)2D3 4. Fetal and Placental Phosphate Metabolism 5. Developmental Aspects of Phosphate Homeostasis 6. Clinical Assessment of Plasma Phosphate and Renal Tubular Threshold for Phosphate 7. Hypophosphatemia and Bone Disease in the Neonatal Intensive Care Unit 8. Nutritional Hypophosphatemia in Children 9.Renal Hypophosphatemia 10. The Young X-Linked Hypophosphatemic (Hyp) Mouse 11. Hypophosphatemia in Disorders of the Parathyroid Hormone and Vitamin D Metabolism 12. Changes in Serum Phosphate Concentration Due to Intercompartmental Shifts 13. Renal Hyperphosphatemia 14. Hormonal Disorders Associated with Hyperphosphatemia 15. Magnetic Resonance in the Investigation of Intracellular Phosphate