Providing a comprehensive review of reactions of oxidation for different classes of organic compounds and polymers, and biological processes mediated by free radicals, Oxidation and Antioxidants in Organic Chemistry and Biology puts the data and bibliographical information you need into one easy-to-use resource. You will find up-to-date information about mechanisms of action of antioxidants, their reactivity, reactions of intermediates, synergism, and antioxidants with cyclic mechanism action. Supplying useful, quantitative data in tables that make the information easy to find, the authors highlight the peculiarities of mechanisms involved in the oxidation of hydrocarbons, polymers, and different organic compounds.
The book provides tabulated values of strengths of C-H bonds of oxygen-containing compounds; of O-H bonds of hydroperoxides, alcohols, and acids; and of attacked antioxidant bonds. The authors collect and discuss over 3000 rate constants of different reactions of peroxyl radicals in oxidation and co-oxidation. They describe a new semiempiric theory of reactivity of reactants in elementary oxidative steps and the algorithm of calculation of activation energies, rate constants, and geometrical parameters of the transition states of free radical reactions. After elucidating the chemistry and kinetics of antioxidant action, the book covers oxidative processes that occur in biological systems.
Table of Contents
CHEMISTRY AND KINETICS OF ORGANIC COMPOUNDS OXIDATION BY DIOXYGEN
Molecular Products and Thermochemistry of Hydrocarbon Oxidation
Chain Mechanism of Liquid-Phase Oxidation of Hydrocarbons
Initiation of Liquid-Phase Oxidation
Oxidation as an Autoinitiated Chain Reaction
Co-Oxidation of Hydrocarbons
Reactivity of the Hydrocarbons in Reactions with Peroxyl, Alkoxyl, and Alkyl Radicals
Oxidation of Alcohols and Ethers
Oxidation of Carbonyl Compounds and Decarboxylation of Acids
Oxidation of Amines, Amides, and Esters
Catalysis in Liquid-Phase Hydrocarbon Oxidation
Sulfoxidation of Hydrocarbons
Oxidation of Polymers
CHEMISTRY OF ANTIOXIDANTS
Theory of Inhibition of Chain Oxidation of Organic Compounds
Antioxidants Reacting with Peroxyl Radicals
Cyclic Chain Termination in Oxidation of Organic Compounds
Hydroperoxide Decomposing Antioxidants
Synergism of Antioxidant Action
Peculiarities of Antioxidant Action in Polymers
Heterogeneous Inhibition of Oxidation
BIOLOGICAL OXIDATION AND ANTIOXIDANTS
Initiators of Free Radical-Mediated Processes
Generation of Free Radicals by Prooxidant Enzymes
Production of Free Radicals by Mitochondria
Production of Free Radicals by Microsomes
Nonenzymatic Lipid Peroxidation
Enzymatic Lipid Peroxidation
Oxidation of Proteins
DNA Oxidative Damage
Free Radicals and Oxidative Stress in Pathophysiological Processes
Comments on Contemporary Methods of Oxygen and Nitrogen Free Radical Detection
"This book presents a comprehensive panorama of the chemistry of oxidation of organic compounds by atmospheric oxygen, and of the properties of antioxidants, both in chemistry and in biology. The kinetics and thermodynamics of the various processes are discussed in great detail, and a large compilation of physicochemical data that are needed to predict the relative importance of the possible reaction paths is presented in the numerous tables. The inclusion of a CD containing a program by which enthalpies of reaction, activation energies, and rate constants can be calculated makes this task even easier."
-Gianfranco Pedulli, Angewandte Chemie International Edition, Vol. 45, No. 29, August 2006
"The book provides up-to-date information about the oxidation of different compounds, antioxidants, and biological oxidation…an excellent source of information not only to the students but also the persons involved in research and academia."
-Carbohydrate Polymers, 2006
"…the authors have conveniently reproduced many figures and schemes directly from their original sources, all of which contribute to a clear visualization of the material covered...the substantial amount of information contained under one cover is definitely the most important asset of this book."
-Gerald B. Hammond, Journal of the American Chemical Society, Vol. 128, No. 13, 2006