Computational Neuroscience: Simulated Demyelinating Neuropathies and Neuronopathies

Diana Ivanova Stephanova, Bozhidar Dimitrov Kolev

January 23, 2013 by CRC Press
Reference - 148 Pages - 38 B/W Illustrations
ISBN 9781466578326 - CAT# K16831


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  • Presents mathematical models for various neurological diseases such as CMT, CIDP, GBS, MMN, and ALS (Lou Gehrig’s disease)
  • Provides explanations of the mechanisms underlying abnormalities in the axonal excitability properties of these diseases
  • Covers the physiological substrates and functioning and the clinical pathology


This book covers the computer simulation of demyelinating neuropathies and neuronopathies and compares models with clinical findings. Through the approximation of nerve excitation and conduction, the authors show how the versatile structure of nerve fibers relates to different modes of focal prospects, inward and outward currents, conduction velocity, and errant transmission. They also explain how mathematical models elucidate emerging fine distinctions between hereditary and acquired neuronal diseases, including Charcot-Marie-Tooth, chronic inflammatory demyelinating polyneuropathy, Guillain-Barre syndrome, multifocal motor neuropathy, and amyotrophic lateral sclerosis.