Tumor-host interaction is critical for cancer proliferation and spread. Tumor mass, metastasis, invasion of host tissue, evasion of the host immune response, and tumor drug resistance are all affected by the interaction between the tumor cell and the host. Molecular strategies to interrupt the tumor-host interaction are among the most promising new leads to emerge in cancer pharmacogenomics and oncogenomics in recent years.
This book critically reviews every aspect of this major topic in cancer research. In the opening chapter, Liang and colleagues describe the use of differential display to identify novel cancer-associated genes. This is followed by a chapter in which Aronow et al. describe possibilities for personalized cancer therapies including the potential new therapies identified by pharmacogenomics. Chapter 3 focuses on novel retinoid derived anti-cancer agents. The following chapters review in detail current advances in the targeting of specific events in cancinogenesis including: apoptosis (chapter 4), metastasis (chapters 6, 13), angiogenesis (chapters 7, 8, 10, 11), TGFb (chapter 5), the endothelin receptor (chapter 9), and drug resistance (chapter 15). This section is followed by two excellent chapters detailing strategies that enlist the assistance of the host immune system (chapters 12 and 14). The closing chapter provides a stimulating insight into current research with suicide gene therapy vectors.
Table of Contents
1. Identification of Target Genes by Differential Display. 2. Oncogenomics: Progress Towards Personalized Molecular Diagnoses and Therapies for Cancer. 3. Cell Differentiation and Cancer Prevention by Retinoids. 4. Apoptosis in Cancer Formation and Progression. 5. Redefining TGFb as a Target in Cancer. 6. Inhibition of Tumor Metastasis by Targeting Metastasis Genes: BRMS1 as a Prototype. 7. Integrins in Angiogenesis: Implications for Tumor Therapy. 8. Anti-angiogenesis in Search of Mechanisms: Angiostatin as a Prototype. 9. Therapeutic Targeting of the Endothelin Receptor in Cancer. 10. Hemostatic Regulators as Drug Targets in Tumor Angiogenesis. 11. Anti-Angiogenesis by Inhibition of Protein Kinase Signaling. 12. Targeting the Immune System to Tumor-Associated Antigens. 13. The Role of Chemokines in Tumor Development and Metastasis. 14. Tumor Killing by Natural Killer Cells. 15. Drug resistance. A Problem and Possible Solutions. 16. Virus Directed Suicide Gene Therapy.
This book is highly useful, and is enthusiastically recommended for cancer researchers and clinicians interested in having an insight into the potential of oncologic treatment - Sinapore Medical Journal (2006: 47(2): 175)
Overall the book is well written and is likely to be uderstood by most researchers and clinicians - Doody Publishing Services