Biomolecular Thermodynamics: From Theory to Application

Douglas Barrick

September 14, 2017 by CRC Press
Textbook - 524 Pages - 255 B/W Illustrations
ISBN 9781439800195 - CAT# K10030
Series: Foundations of Biochemistry and Biophysics

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  • Emphasizes problem solving using both real and simulated data
  • Develops multiple skill sets, including data analysis and mathematical simulation
  • Covers various biochemical problems, including conformational equilibria, ligand binding, chemical denaturation, proton titration, helix-coil transition theory, allostery, and catalysis
  • Offers a concise yet thorough and novel approach to understanding the essential aspects of physical chemistry without dry theoretical discussion
  • Shows how to apply classical and statistical thermodynamics to complicated biochemical processes, such as ligand binding, cooperativity, and assembly


"an impressive text that addresses a glaring gap in the teaching of physical chemistry, being specifically focused on biologically-relevant systems along with a practical focus…. the ample problems and tutorials throughout are much appreciated."
–Tobin R. Sosnick, Professor and Chair of Biochemistry and Molecular Biology, University of Chicago

"Presents both the concepts and equations associated with statistical thermodynamics in a unique way that is at visual, intuitive, and rigorous. This approach will greatly benefit students at all levels."
–Vijay S. Pande, Henry Dreyfus Professor of Chemistry, Stanford University

"a masterful tour de force…. Barrick's rigor and scholarship come through in every chapter."
–Rohit V. Pappu, Edwin H. Murty Professor of Engineering, Washington University in St. Louis

This book provides a comprehensive, contemporary introduction to developing a quantitative understanding of how biological macromolecules behave using classical and statistical thermodynamics. The author focuses on practical skills needed to apply the underlying equations in real life examples. The text develops mechanistic models, showing how they connect to thermodynamic observables, presenting simulations of thermodynamic behavior, and analyzing experimental data. The reader is presented with plenty of exercises and problems to facilitate hands-on learning through mathematical simulation.


Douglas E. Barrick is a professor in the Department of Biophysics at Johns Hopkins University. He earned his Ph.D. in biochemistry from Stanford University, and a Ph.D. in biophysics and structural biology from the University of Oregon.

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