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Aquaporins in Health and Disease: New Molecular Targets for Drug Discovery

Graca Soveral, Soren Nielsen, Angela Casini
November 01, 2017

Since the discovery of Aquaporin-1 (AQP1) as a water channel, many studies have revealed the importance of aquaporins in mammalian physiology and pathophysiology as well as plant and microbial biology. The studies have also shown aquaporins as potential drug targets and targets for improving crop...

Computational Optical Biomedical Spectroscopy and Imaging

Sarhan M. Musa
October 31, 2017

Computational Optical Biomedical Spectroscopy and Imaging covers recent discoveries and research in the field by some of the best inventors and researchers in the world. It also presents useful computational methods and applications used in optical biomedical spectroscopy and imaging. Topics...

Coarse-Grained Modeling of Biomolecules

Garegin A. Papoian
October 30, 2017

"The chapters in this book survey the progress in simulating biomolecular dynamics…. The images conjured up by this work are not yet universally loved, but are beginning to bring new insights into the study of biological structure and function. The future will decide whether this scientific...

Metalloproteins: Theory, Calculations, and Experiments

Art E. Cho, William A. Goddard III
October 26, 2017

Numerous essential biological functions involve metalloproteins; therefore, understanding metalloproteins and how to manipulate them is significant in the biological and medical fields. An examination of current research, Metalloproteins: Theory, Calculations, and Experiments explores the interplay...

Biomolecular Kinetics: A Step-by-Step Guide

Clive R. Bagshaw
October 16, 2017

"a gem of a textbook which manages to produce a genuinely fresh, concise yet comprehensive guide"–Mark Leake, University of York "destined to become a standard reference…. Not just a ‘how to’ handbook but also an accessible primer in the essentials of kinetic theory and practice."–Michael Geeves,...

Introduction to Experimental Biophysics, Second Edition: Biological Methods for Physical Scientists

Jay L. Nadeau
October 05, 2017

Praise for the First Edition “essential reading for any physical scientist who is interested in performing biological research.” ―Contemporary Physics "an ambitious text…. Each chapter contains protocols and the conceptual reasoning behind them, which is often useful to physicists performing...

Sedimentation Velocity Analytical Ultracentrifugation: Interacting Systems

Peter Schuck, Huaying Zhao
October 04, 2017

Analytical ultracentrifugation is one of the most powerful solution techniques for the study of macromolecular interactions, to define the number and stoichiometry of complexes formed, and to measure affinities ranging from very strong to very weak and repulsive. Building on the data analysis...

Biomolecular Thermodynamics: From Theory to Application

Douglas Barrick
September 14, 2017

"an impressive text that addresses a glaring gap in the teaching of physical chemistry, being specifically focused on biologically-relevant systems along with a practical focus…. the ample problems and tutorials throughout are much appreciated." –Tobin R. Sosnick, Professor and Chair of...

Advanced Electroporation Techniques in Biology and Medicine

Andrei G. Pakhomov, Damijan Miklavcic, Marko S. Markov
September 12, 2017

A reflection of the intense study of the effects of electromagnetic fields on living tissues that has taken place during the last decades, Advanced Electroporation Techniques in Biology and Medicine summarizes most recent experimental findings and theories related to permeabilization of...

Chromatin: Structure, Dynamics, Regulation

Ralf Blossey
July 21, 2017

An invaluable resource for computational biologists and researchers from other fields seeking an introduction to the topic, Chromatin: Structure, Dynamics, Regulation offers comprehensive coverage of this dynamic interdisciplinary field, from the basics to the latest research. Computational methods...

Microdosimetry: Experimental Methods and Applications

Lennart Lindborg, Anthony Waker
July 11, 2017

Experimental microdosimetry deals with the measurement of charged particle energy deposition in tissue equivalent volumes, ranging in size from nanometres to micrometres. Microdosimetry is employed to improve our understanding of the relationship between radiation energy deposition, the resulting...

An Introduction to Physical Oncology: How Mechanistic Mathematical Modeling Can Improve Cancer Therapy Outcomes

Vittorio Cristini, Eugene Koay, Zhihui Wang
July 06, 2017

Physical oncology has the potential to revolutionize cancer research and treatment. The fundamental rationale behind this approach is that physical processes, such as transport mechanisms for drug molecules within tissue and forces exchanged by cancer cells with tissue, may play an equally...