Handbook of Clinical Nanomedicine: From Bench to Bedside

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ISBN 9789814316170
Cat# N10834

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Features

  • Examines the entire "product wheel" from creation of nanomedical products to final market introduction
  • Designed for the novice and expert alike in fields such as medicine, law, biotechnology, pharmaceutical sciences, engineering, biomedicine, policy, future studies, ethics, intellectual property law, licensing, and toxicology
  • Addresses critical topics such as ethics, safety and toxicity, environmental health, nanoeconomics, business strategy, licensing, intellectual property, FDA law, EPA law, and governmental policy issues

Summary

The enormous advances in nanomedicine in the past decade have necessitated a growing need for an authoritative and comprehensive reference source that can be relied upon by scientists, clinicians, students, and industry and policy makers alike. The Handbook of Clinical Nanomedicine: From Bench to Bedside is designed to offer a global perspective on the wonders of nanomedicine.

The handbook aims to provide a broad survey of various interconnected topics pertaining to nanomedicine. It is intended to be a stand-alone, easily accessible volume that examines the entire "product wheel" from creation of nanomedical products to final market introduction, all accomplished in a user-friendly format. Specifically, everything from bio-nanomaterials and nanodevices from the R&D stage to patent protection, clinical regulatory aspects, and eventual commercialization is encompassed in this book. In addition to highlighting cutting-edge technologies, the book addresses critical topics such as ethics, safety and toxicity, environmental health, nanoeconomics, business strategy, licensing, intellectual property, FDA law, EPA law, and governmental policy issues. With contributions from international experts, the diverse team of editors has compiled a book that provides a unified perspective to these varied topics. While many books focus on nanomedicine, nanotechnology, or nanoscience, none provide the medical applications of nanotechnology with both a clinical and business angle. Furthermore, most of the currently available books on the market fail to highlight the truly global nature of nanomedicine.

The handbook, divided into four sections, provides a comprehensive road map of basic research in nanomedicine as well as clinical applications and commercialization activities. Each of the 45-plus chapters contains 10–20 key words, extensive tables, color figures, future projections, and an extensive list of references. The handbook is an essential reading for the novice and expert alike in fields such as medicine, law, biotechnology, pharmaceutical sciences, engineering, biomedicine, policy, future studies, ethics, intellectual property law, licensing, and toxicology. While bridging the gap between basic biomedical research, engineering, and medicine, the handbook provides an understanding of nanotechnology’s

  • use to solve medical problems
  • current applications and their potential
  • regulatory environment and policy issues
  • intellectual property, licensing, and business activities

It is clear that the well-known editors have skillfully selected and thoroughly edited each chapter to reflect the most updated information possible. The range of topics covered as well as the international selection of authors is truly impressive. Since the rapidly evolving field of nanomedicine is very diverse and covers physical, chemical, biological, and engineering aspects, the range of the contributing authors accurately reflects this. The book’s multidisciplinary approach and an in-depth focus on nanomedicine, pharmaceutical sciences, materials science, biomedical engineering, and biotechnology will attract a global audience. In short, Handbook of Clinical Nanomedicine: From Bench to Bedside promises to be a standard reference text in this expansive and interdisciplinary field. It is a timely addition to the literature on nanosciences and will undoubtedly serve as a catalyst to stimulate interest in this rapidly growing field.

Table of Contents

General
Science at the nanoscale: Introduction and historical perspective
Song, Haur and Wee
Nanomedicine: Dynamic integration of nanotechnology with biomedical science
Lee, Solanki, Kim, Jung
Defining nanotechnology and nanomedicine – big issue in small science
Bawa
Nano-therapeutics and the future of medicine
Bawa, Bawa and Mehra
Top ten recent nanomedical advances
Swan

Nanosystems, Nanodevices and Imaging Tools
Nanosizing approaches in drug delivery
Chavhan, Petkar and Sawant
Design and development of approved nanopharmaceutical products
Mansour, Park and Bawa
Designing nanocarriers for the effective treatment of cardiovascular diseases
Vaidya and Vyas
Nanoparticles for multi-modality diagnostic imaging and drug delivery
Lockhart and Ho
Magnetic nanoparticles in magnetic resonance imaging: A translational push toward theranostics
Ortega, Yankeelov and Giorgio
Atomic force microscopy for nanomedicine
Sharma and Gimzewski
Advances in the use of nanomedicine for medical imaging
Dearling and Packard
Image-based high-content analysis, stem cells and nanomedicines: A novel strategy for drug discovery
Solomesky, Adalist and Weil
AFM imaging and probing amyloid nanoaggergates
Lyubchenko
Intracellular transport and unpacking of polyplex nanoparticles
Rosenkranz, Khramtsov, Ulasov, Rodichenko and Sobolev
Cell and protein interactions with small-scale diamond materials
Narayan, Boehm and Monteiro-Riviere
Bacterial secretion systems: nanomachines for infection and genetic diversity
Shala, Ferarro and Audette
Viral nanoparticles: Tools for materials science and biomedicine
Steinmetz and Manchester

Clinical Applications
Polysaccharides as nanomaterials for therapeutics
Mizrahy and Peer Diwan
Aptamers in clinical trials
Kanwar, Roy, Kanwar and Bawa
Nanotechnology and the skin barrier: topical and transdermal nanocarrier-based delivery
Labouta and Schneider
Transdermal immunotherapy with synthetic pathogen-like nanomedicines and its clinical application towards the cure of HIV
Lorincz and Lisziewicz
Application of nanotechnology in non-invasive topical gene therapy
Esabahy, Jimena Loureiro and Foldvari
Nanocarriers in the therapy of inflammatory disease
Lamprecht
Nanomedicine challenges in thrombosis
Karagkiozaki
Nanomedicine for cardiovascular disease: Potentials and Challenges
Karagkiozaki
Nanomedicine for acute lung injury/acute respiratory distress syndrome: a shifting paradigm?
Sadikot and Rubinstein
Multilayered nanoparticles for personalized medicine: translation into clinical markets
Prina-Mello
Carbon nanotubes as substrates for neuronal growth
Ménard-Moyon
Polymeric nanoparticles for cancer therapeutics
Verma, Rosen, Meerasa, Yoffe and Gu
Nanotechnology for radiation oncology
Sridhar, Berbeco, Cormack, and Makrigiorgos
Solid lipid nanoparticles and nanostructured lipid carriers for cancer therapy
Uner
Nanoparticles for brain cancer therapy
Agarwal, Tiwari, Agrawal
Complement activation: a capricious immune barrier to nanomedicine clinical application
Szebeni

Regulatory Issues, Toxicology, Intellectual Property and Nano-Ethics
Regulating nanomedicine at the FDA and EPA
Hartman, Bawa, Monica
Regulatory aspects of nanomedicine in Europe
D’Silva
Managing environmental and health risks in the nanotechnology industry
Huan
Toxicity of silicon dioxide nanoparticles in mammalian neural cells
Lai, Jaiswal, Lai, Jandhyam, Leung and Bhushan
An intellectual property primer for nanomedical researchers and engineers
Reese
Strategic intellectual property management – building IP portfolios
Langer
IP Valuation: principles and applications in the nanotechnology industry
Kasznik
Extending patent term for nanomedical inventions – A nexus between the FDA and the patent system
Hopkins
Technology transfer: An overview
Goldstein
Licensing issues in nanotechnology
Brougher
The Tower of Babel: miscommunication within and about nanomedicine
Juliano
Clinical nanobioethical problems: a value approach
Álvarez-Díaz
The audience is the message: nanomedicine as apotheosis or damnatio memoriae
Berube