This book contains papers which discuss many different stimulus--response systems ranging from those in bacteria and paramecia to those in insects and mammals. Emphasis is placed on the identification and characterization of receptor molecules, physical properties of channel molecules, physical and chemical changes in receptors, channels and other structures after stimuli, and the molecular events in the sequential response, excitation, adaptation and learning phases. Use is made throughout of both traditional and new techniques in electrophysiology, biochemistry, genetics and ultrastructural analysis. By covering a wide range of stimulus--response systems the book invites comparison between systems and generates discussion about common principles underlying information reception, transduction and response.
Dynamics of phospholipids and calcium in secretory cells A. Imai, K. Yano, S. Nakashima, Y. Ishizuka, H. Hattori, M. Takahashi and Y. Nozawa Properties and funcions of enzymes hydrolysing inositol phospholipid R.F. Irvine, A.J. Letcher, D.L. Lander and R.M.C. Dawson Possible involvement of proteases in phosphatidylinositol turnover K. Hirasawa Calcium and phospholipid turnover in signal transduction: a mechanism of action of phorbol ester Kikkawa Transmembrane signalling in areas of cell contact B. Geiger The cytoskeleton underlying the axolemma S. Tsukita and S. Tsukita Involvement of phospholipid metabolism in visual transduction H. Inoue and T. Yoshioka Phosphoinositides in the auditory system J. Schacht Characterization of biomembranes within the cochlea M. Tachibana Aminoglycoside blockade of cation channels from polyphosphoinositides and sarcoplasmic reticulum in planar bilayer membranes M. Sokabe Thermosensory transduction in Paramecium Y. Nakaoka Genetics of sensory transducers in Escherichia coli J.S. Parkinson, A.M. Callahan and M.K. Slocum Biochemical studies on bacterial chemotaxis: an in vitro system of methylation of methyl-accepting chemotaxis proteins S. Minoshima and H. Hayashi Retinal-containing proteins in Halobacterium halobium J.L. Spudich Thermosensory transduction in Escherichia coli T. Mizuno, K. Maeda and Y. Imae Reconstitution of ionic channels into lipid bilayer membranes R. Latorre and D. Benos Ion permeation through sarcoplasmic reticulum membrane K. Nunogaki and M. Kasai Modulation of a specific K channel in Aplysia neurons by serotonin and c-AMP J. Camardo ATP-dependent uptake of glutamate into synaptic vesicles T. Ueda