The foundational reference in dermal toxicology, this classic text has been completely revised to bring it up to date in the new Eighth Edition, with almost a third of its chapters being newly added. The structure of the text has also been reorganized to enable easier location of a topic of interest. With contributions from leading international experts, this continues the tradition of providing unsurpassed theoretical and practical guidance for all those working on research aspects, on practical clinical issues, and on the regulatory aspects of exposure to toxic substances.
This new edition contains updates to each chapter and contributions from leading international experts, provides an in-depth summary of research and regulatory applications related to dermal toxicology and pharmacology, presents many new chapters that describe the latest advances in dermatotoxicology, and addresses various levels of expertise regarding the development and use of dermal exposure data. New chapters include those on safety terminology, pharmacogenetics and dermatology, ethnic differences in skin properties, and the principles and practice of percutaneous absorption.
I: Concepts 1. Pharmacogenetics and dermatology 2. Hormesis and dermatology 3.Toward an evidence-based dermatotoxicology 4. How to improve skin notation 5. Skin ion channels in health and disease II: Systemic Toxicity 6. Systemic toxicity 7. Chemical respiratory allergy: opportunities for hazard identification and characterization 8. Nephrotoxicity of organic solvents from skin exposure 9. Mechanisms in cutaneous drug hypersensitivity reactions 10. Systemic allergic (contact) dermatitis III: Local Toxicity 11. Immunological mechanisms in irritant and allergic contact dermatitis 12. Allergic contact dermatitis: elicitation thresholds of potent allergens in humans 13. Photoirritation 14. Contact urticaria syndrome IV: Compounds 15. Percutaneous penetration enhancers: overview 16. Chemical warfare agents 17. Allergic contact dermatitis from ophthalmics 18. Textiles and human skin, microclimate, and cutaneous reactions: overview 19. Identifying the source of textile-dye allergic contact dermatitis: a guideline 20. Trichloroethylene dermatotoxicology: an update 21. Chemical agents that cause depigmentation 22. Hydroxychloroquine-induced retinopathy 23. Factors influencing applied amount of topical preparations 24. Immune reactions to copper 25. Sodium lauryl sulfate 26. Water: is it an irritant? 27. In vivo human transfer of topical bioactive drugs among individuals: estradiol and testosterone 28. Depigmentation changes as a result of arsenic exposure V: Susceptibility of Different Populations 29. Gender and pharmacokinetics 30. Dermatological drug usage in the elderly 31. Sensitive skin: A valid syndrome of multiple origins 32. Dermatotoxicology of the vulva 33. Human scalp irritation related to arm and back 34. Functional map and age-related differences in human faces: nonimmunologic contact urticaria induced by hexyl nicotinate 35. Adhesive tape stripping reveals differences in stratum corneum cohesion between Caucasians, Blacks and Hispanics as a function of age VI: Methods 36. Animal, human, and in vitro test methods for predicting skin irritation 37. Physiologically based pharmacokinetic modelling of dermal absorption 38. In vitro approaches to assessment of skin irritation and phototoxicity of topically applied materials 39. The local lymph node assay 40. Utilization of irritation data in local lymph node assay 41. Failure of standard test batteries for detection of genotoxic activity of some chemicals used in dermatological and cosmetic products 42. Determination of chromium and nickel allergy, sensitization, and toxicity by cellular in vitro methods 43. Methods for in vitro skin metabolism 44. In vitro model for decontamination of human skin: formaldehyde 45. Percutaneous absorption of hazardous substances from soil and water 46. Stratum corneum tape stripping method: an update 47. The diagnostic value of patch testing 48. Diagnostic tests in dermatology: patch and photopatch testing and contact urticaria 49. Photoirritation (phototoxicity or phototoxic dermatitis) 50. Significance of methyl mercury hair analysis: mercury biomonitoring in human scalp/nude mouse model 51. Use of modified forearm controlled application text to evaluate skin irritation of lotion formulations 52. Evaluating mechanical and chemical irritation using the behind-the-knee test: a review 53. Tests for sensitive skin 54. Dermatotoxicity of specialized epithelia: adapting cutaneous test methods to assess topical effects on the vulva 55. Biomarkers associated with severe cutaneous adverse reactions VII: Treatment 56. Decreasing allergic contact dermatitis frequency through dermatotoxicologic and epidermic-based intervention 57. The importance of the skin decontamination wash-in effect 58. Water decontamination of chemical skin and eye splashes: a critical review 59. Irritant and allergic contact dermatitis treatment 60. Anti-irritants: myth or reality? An overview VIII: Regulatory Aspects and Guidelines 61. Validation and regulatory acceptance of dermatotoxicology methods: recent progress and the role of NICEATM and ICCVAM 62. Safety and efficacy information in drug inserts for topical prescription medications 63. Lack of drug interaction conformity in commonly used drug compendia for selected at-risk dermatologic drugs 64. OECD guidelines for testing of chemicals 65. Dermatologic drugs withdrawn by the FDA for safety reasons
Klaus-Peter Wilhelm, M.D., is extraordinary professor of dermatology at the University of Lübeck, Germany, and president and medical director of proDERM Institute for Applied Dermatological Research Schenefeld/Hamburg, Germany. He is president of the International Society for Biophysics and Imaging of the Skin, and a member of several scientific associations and societies. He has published over 100 manuscripts and reviews and coauthored three books in the bioengineering of the skin series. Dr. Wilhelm received an M.D. from the Medical University of Lübeck, Germany.
Hongbo Zhai, M.D., is a senior research fellow at the Department of Dermatology in the University of California at San Francisco. He has over two decades of experience in the prevention of contact dermatitis and the development of skin-disease-related products. He has contributed to the development of innovative skin-related products in collaboration with many global pharmaceutical and cosmetic companies. He has published more than 100 scientific articles in his research areas. Dr. Zhai is also the 2003 winner of the international “Niels Hjorth Prize.”
Howard I. Maibach, M.D., is professor of dermatology in the School of Medicine at the University of California, San Francisco. He has several decades of research experience in skin diseases and the development of skin-related products. He has published more than 2,000 papers and over 80 textbooks. He is a consultant to government agencies, universities, and industry.