- Contains many exercises of varying difficulty often drawn from real-life applications, especially in the health sciences
- Explains the theoretical biostatistical principles needed to solve the exercises
- Includes detailed solutions to all exercises
- Presents useful mathematical results in an appendix

Drawn from nearly four decades of Lawrence L. Kupper’s teaching experiences as a distinguished professor in the Department of Biostatistics at the University of North Carolina, **Exercises and Solutions in Biostatistical Theory** presents theoretical statistical concepts, numerous exercises, and detailed solutions that span topics from basic probability to statistical inference. The text links theoretical biostatistical principles to real-world situations, including some of the authors’ own biostatistical work that has addressed complicated design and analysis issues in the health sciences.

This classroom-tested material is arranged sequentially starting with a chapter on basic probability theory, followed by chapters on univariate distribution theory and multivariate distribution theory. The last two chapters on statistical inference cover estimation theory and hypothesis testing theory. Each chapter begins with an in-depth introduction that summarizes the biostatistical principles needed to help solve the exercises. Exercises range in level of difficulty from fairly basic to more challenging (identified with asterisks).

By working through the exercises and detailed solutions in this book, students will develop a deep understanding of the principles of biostatistical theory. The text shows how the biostatistical theory is effectively used to address important biostatistical issues in a variety of real-world settings. Mastering the theoretical biostatistical principles described in the book will prepare students for successful study of higher-level statistical theory and will help them become better biostatisticians.

**Basic Probability Theory**

Counting Formulas (N-tuples, permutations, combinations, Pascal’s identity, Vandermonde’s identity)

Probability Formulas (union, intersection, complement, mutually exclusive events, conditional probability, independence, partitions, Bayes’ theorem)

**Univariate Distribution Theory**

Discrete and Continuous Random Variables

Cumulative Distribution Functions

Median and Mode

Expectation Theory

Some Important Expectations (mean, variance, moments, moment generating function, probability generating function)

Inequalities Involving Expectations

Some Important Probability Distributions for Discrete Random Variables

Some Important Distributions (i.e., Density Functions) for Continuous Random Variables

**Multivariate Distribution Theory**

Discrete and Continuous Multivariate Distributions

Multivariate Cumulative Distribution Functions

Expectation Theory (covariance, correlation, moment generating function)

Marginal Distributions

Conditional Distributions and Expectations

Mutual Independence among a Set of Random Variables

Random Sample

Some Important Multivariate Discrete and Continuous Probability Distributions

Special Topics of Interest (mean and variance of a linear function, convergence in distribution and the Central Limit Theorem, order statistics, transformations)

**Estimation Theory**

Point Estimation of Population Parameters (method of moments, unweighted and weighted least squares, maximum likelihood)

Data Reduction and Joint Sufficiency (Factorization Theorem)

Methods for Evaluating the Properties of a Point Estimator (mean-squared error, Cramér–Rao lower bound, efficiency, completeness, Rao–Blackwell theorem)

Interval Estimation of Population Parameters (normal distribution-based exact intervals, Slutsky’s theorem, consistency, maximum-likelihood-based approximate intervals)

**Hypothesis Testing Theory**

Basic Principles (simple and composite hypotheses, null and alternative hypotheses, Type I and Type II errors, power, P-value)

Most Powerful (MP) and Uniformly Most Powerful (UMP) Tests (Neyman–Pearson Lemma)

Large-Sample ML-Based Methods for Testing a Simple Null Hypothesis versus a Composite Alternative Hypothesis (likelihood ratio, Wald, and score tests)

Large-Sample ML-Based Methods for Testing a Composite Null Hypothesis versus a Composite Alternative Hypothesis (likelihood ratio, Wald, and score tests)

**Appendix: Useful Mathematical Results**

**References **

**Index**

*Exercises and Solutions appear at the end of each chapter.*

**Lawrence L. Kupper, Ph.D.,** is an emeritus alumni distinguished professor of biostatistics at the University of North Carolina at Chapel Hill. Dr. Kupper has received several teaching and research awards during his career and has been involved with many research areas in the health sciences, including epidemiology, environmental and occupational health, maternal and child health, and medicine. His research interests concern the development of innovative biostatistical methods for the design and analysis of public health research studies.

**Brian H. Neelon, Ph.D.,** is a research statistician with the Children’s Environmental Health Initiative (CEHI) in the Nicholas School of the Environment at Duke University. Before working at Duke University, Dr. Neelon was a Postdoctoral Research Fellow in the Department of Health Care Policy at Harvard University. He earned his Ph.D. from the University of North Carolina. His research interests include Bayesian methods, longitudinal data analysis, finite mixture models, and health policy statistics.

**Sean M. O’Brien, Ph.D.,** is an assistant professor of biostatistics and bioinformatics at the Duke University School of Medicine. Dr. O’Brien earned his Ph.D. from the University of North Carolina. His research interests include statistical methods for healthcare provider profiling, observational studies, and Bayesian data analysis.

"This book is a rich collection of class-tested material given in the form of exercises followed by their complete solutions. … The material is well chosen and well structured. … The exercises are of a different nature: some are relatively elementary; others are more advanced. This makes the book useful for both undergraduate and graduate courses. The solutions are so detailed that the book can be used for self-learning. The authors are successful in presenting elements of statistical theory and also in showing how to answer important questions when analysing statistical models of real-life phenomena. … It is of no doubt that it will be useful for students and their teachers."

—Jordan Stoyanov, *Journal of the Royal Statistical Society, Series A*, February 2014

"I can highly recommend this book for readers who are interested in learning statistical theory and its applications. The book provides good supplementary material for various teaching purposes in biostatistics, but also for self-study for anyone who is willing to deepen their theoretical knowledge in statistics using good examples."

—*International Statistical Review*, 2013

"… this book provides a nice collection of problems in statistical theory. It is definitely useful for students who need additional problems for practice. It is also helpful for instructors who seek extra problems for their lectures, homework, and exams. In fact, I used one problem in my mid-term exam while I was reviewing this book."

—Kui Zhang, *The American Statistician*, November 2013

"… it should appeal to a broader audience of anyone interested in mastering the concepts of probability and mathematical statistics at the advanced undergraduate and beginning graduate levels … Students and instructors of such courses as well as anyone studying on their own to brush up their knowledge of statistical theory will find the book very useful. … Overall, I like this book very much. The problems are carefully chosen and cover a wide range of real-world applications of biostatistical methods. Instructors and students will find this book to be a good source of supplementary problems for practice. … I have taught courses in mathematical statistics on several prior occasions and wish a book like this was available earlier."

—Kaushik Ghosh, *Journal of Biopharmaceutical Statistics, *Vol. 22, 2012

"… a fairly extensive collection of problems such as might be used in a senior undergraduate or first year graduate mathematical statistics course aimed at biostatistics majors. … this book would definitely be of value to students who wanted additional examples and problems related to the material most commonly encountered in a first mathematical statistics course. … I have recommended the book to some of my graduate students who are studying for their qualifying exams. … I would also think that it would be of use to instructors who were interested in identifying examples for use in their lectures, homework, or examinations."

—Scott Emerson, *Biometrics*, June 2011