Multiple Comparisons Using R

Multiple Comparisons Using R

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Features

    • Covers a range of multiple comparison procedures, from the Bonferroni method and Simes’ test to resampling and adaptive design methods
    • Discusses how to prevent finding artifacts through unreasonable or excessive data manipulation
    • Examines the ability to state rigorous claims in spite of the hazards of multiplicity
    • Provides the theoretical framework for various applications
    • Focuses on classical applications of multiple comparison procedures
    • Explores how to determine what is a safe and effective dose as well as whether a new condition or treatment is successful
    • Implements many examples using R
    • Offers R packages and source code at http://CRAN.R-project.org

    Summary

    Adopting a unifying theme based on maximum statistics, Multiple Comparisons Using R describes the common underlying theory of multiple comparison procedures through numerous examples. It also presents a detailed description of available software implementations in R. The R packages and source code for the analyses are available at http://CRAN.R-project.org

    After giving examples of multiplicity problems, the book covers general concepts and basic multiple comparisons procedures, including the Bonferroni method and Simes’ test. It then shows how to perform parametric multiple comparisons in standard linear models and general parametric models. It also introduces the multcomp package in R, which offers a convenient interface to perform multiple comparisons in a general context. Following this theoretical framework, the book explores applications involving the Dunnett test, Tukey’s all pairwise comparisons, and general multiple contrast tests for standard regression models, mixed-effects models, and parametric survival models. The last chapter reviews other multiple comparison procedures, such as resampling-based procedures, methods for group sequential or adaptive designs, and the combination of multiple comparison procedures with modeling techniques.

    Controlling multiplicity in experiments ensures better decision making and safeguards against false claims. A self-contained introduction to multiple comparison procedures, this book offers strategies for constructing the procedures and illustrates the framework for multiple hypotheses testing in general parametric models. It is suitable for readers with R experience but limited knowledge of multiple comparison procedures and vice versa.

    See Dr. Bretz discuss the book.

    Table of Contents

    Introduction

    General Concepts
    Error rates and general concepts
    Construction methods
    Methods based on Bonferroni’s inequality
    Methods based on Simes’ inequality

    Multiple Comparisons in Parametric Models
    General linear models
    Extensions to general parametric models
    The multcomp package

    Applications
    Multiple comparisons with a control
    All pairwise comparisons
    Dose response analyses
    Variable selection in regression models
    Simultaneous confidence bands
    Multiple comparisons under heteroscedasticity
    Multiple comparisons in logistic regression models
    Multiple comparisons in survival models
    Multiple comparisons in mixed-effects models

    Further Topics
    Resampling-based multiple comparison procedures
    Group sequential and adaptive designs
    Combining multiple comparisons with modeling

    Bibliography

    Index

    Author Bio(s)

    Frank Bretz is Global Head of the Statistical Methodology group at Novartis Pharma AG in Basel, Switzerland. He is also an adjunct professor at the Hannover Medical School in Germany.

    Torsten Hothorn is a professor of biostatistics in the Faculty of Mathematics, Computer Science and Statistics at Ludwig-Maximilians-Universität München in Germany.

    Peter Westfall is James and Marguerite Niver and Paul Whitfield Horn Professor of Statistics and associate director of the Center for Advanced Analytics and Business Intelligence at Texas Tech University in Lubbock, USA.

    Editorial Reviews

    The book is primarily targeted at practitioners who will find the illustrative examples utilizing real data helpful. Methodologically interested readers are provided with interesting concepts and a good survey on multiple comparisons literature in the bibliography.
    —Thorsten Dickhaus, Biometrics, September 2012

    Nice stand-out features of the book are its clarity and conciseness, its coverage of group sequential and adaptive designs, and the nice illustration through actual problems using R software and the CRAN library of R routines for multiple testing. … useful for statistical consultants and graduate students who perhaps cannot afford a SAS license. … Another nice feature of the book is its organization.
    —Michael R. Chernick, Technometrics, August 2011

    An excellent first chapter gently explains to the reader why multiple comparison techniques are required. Successive chapters delve into more and more sophisticated scenarios for multiple comparisons. The benefits of applying multiple testing in the context of ordinary linear models are in my opinion not often stressed in undergraduate statistics courses. It was refreshing to see an entire chapter devoted to this idea. The over 150 references make this an excellent entry point into the literature … Do consider it [the book] if you are a user of R, who is also a researcher or teacher of linear modelling, and needs to apply multiple comparisons in their work. Your work will be the better for it.
    —Alice Richardson, International Statistical Review (2011), 79

    I found the book to be a rare gem; it is very seldom indeed that a reviewer has difficulty finding things to criticize. The book is concise, but covers all the common topics and a little more. It is simply written, yet manages to explain the key concepts remarkably well. Above all, it introduces a comprehensible structure that unifies seemingly different methodologies into a single system. … I believe this book could be useful to all those seeking guidance [on] the multitude of multiplicity correcting procedures. … The authors managed to create a fine balance between theory and practical applications … The book is warmly recommended.
    —Vera Lisovskaja, Journal of Biopharmaceutical Statistics, Vol. 21, 2011