Describes the state-of-the-art techniques and methods involved in the design, operation, preparation and containment of bioreactor systems, taking into account the interrelated effects of variables associated with both upstream and downstream stages of the design process. The importance of the initial steps in the development of a bioprocess, such as strain and media selection, that have an overwhelming influence on all further operations, is emphasized.;This work is intended for biochemical, chemical and bioprocess engineers; biotechnologists; industrial biochemists; micro- and molecular biologists; food scientists; and upper-level undergraduate and graduate students in these disciplines.
Series Introduction W. Courtney McGregor
Foreword Eleftherios Terry Papoutsakis
Preface
Contributors
Design of a Bioreactor System: Overview
José C. Merchuk and Juan A. Asenjo
Part I: Biological Systems and Media Design
Organism Selection
Francisco Javier Castillo
Bacterial, Yeast, and Fungal Cultures: Effect of Microorganism Type and Culture Characteristics on Bioreactor Design and Operation
Moshe D. White, Bernard R. Glick, and Campbell W. Robinson
Design, Formulation, and Optimization of Media
Rodolfo J. Ertola, Ana Maria Giulietti, and Francisco Javier Castillo
Part II: Bioreactor Design
Fundamentals of Bioreactor Design
José C. Merchuk and Juan A. Asenjo
Stirred Tank Bioreactors
Matthias Reuss
Pneumatically Agitated Bioreactors
Karl Schügerl and Andreas Lübbert
Membrane Reactors
Peter M. Salmon and Channing R. Robertson
Immobilized Microorganism Bioreactors
Hideki Fukuda
Immobilized Animal Cell Bioreactors
Matthew S. Croughaun, Tzyy-Wen Chiou, and Daniel I. C. Wang
Plant Cell Bioreactors
Peter D. G. Wilson and Martin G. Hilton
Photobioreactors
Aleś Prokop and Larry E. Erickson
Bioreactor Operation Modes
Tsuneo Yamane
Scale-Up
Carles Solá and Francesc Gòdia
Part III: Bioreactor Support Systems
Sterilization and Containment
Andrew Sinclair and Michael H. J. Ashley
Bioreactor System Supplies
T. M. Roberts, M. J. Kearns, and T. J. Latham
Index
Biography
Juan A. Asenjo