This book covers the fundamentals of the rapidly growing field of biothermodynamics, showing how thermodynamics can best be applied to applications and processes in biochemical engineering. It describes the rigorous application of thermodynamics in biochemical engineering to rationalize bioprocess development and obviate a substantial fraction of this need for tedious experimental work. As such, this book will appeal to a diverse group of readers, ranging from students and professors in biochemical engineering, to scientists and engineers, for whom it will be a valuable reference.
The Role of Thermodynamics in Biochemical Engineering. Phase Equilibrium in Non-Electrolyte Systems. Virial Expansion for Chemical Potentials in a Dilute Solution for Calculation of Liquid-Liquid Equilibria. Water. Thermodynamics of Electrically Charged Molecules in Solution. Polymers, Polyelectrolytes and Gels. Molecular Thermodynamics of Partitioning in Aqueous Two-Phase Systems. Generalization of Thermodynamic Properties for the Selection of Bioseparation Processes. Self-Assembly of Amphiphilic Molecules. Proteins. Thermodynamics in Multiphase Catalysis. Protein Precipitation with Salts and Polymers. Thermodynamics of the Physical Stability of Protein Solutions. The Stabilities and Melting Temperatures of B-Form DNA. Multicomponent Ion Exchange Equilibria of Weak-Electrolyte Biomolecules. Live Cells as Non-equilibrium Systems. Miniaturization of Calorimetery: Strengths and Weaknesses for Bioprocess Monitoring and Control. A Thermodynamic Approach to Predict Black-Box Model Parameters for Microbial Growth. Biothermodynamics of Live Cells: Energy Dissipation and Heat Generation in Cellular Cultures. Thermodynamic Analysis of Photosynthesis. Thermodynamic Analysis of Dicarboxylic Acid Production in Microorganisms. Thermodynamic Analysis of Metabolic Pathways.