Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds

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Features

  • Focuses on recent achievements in bioactive natural compounds and their structure-activity relationships
  • Presents the chemistry and pharmaceutical potential of natural products in modern drug discovery processes
  • Features chemical advances in naturally occurring organic compounds
  • Presents the synthesis and semi-synthesis of potentially bioactive natural products
  • Includes spectral and X-ray properties of featured natural products
  • Covers plant tissue cultures and fermentation improvement processes yielding natural products for industry

Summary

Natural products play crucial roles in modern drug development, and constitute a prolific source of novel lead compounds or pharmacophores for ongoing drug discovery programs. Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds presents cutting-edge research in the chemistry of bioactive natural products and demonstrates how natural product research continues to make significant contributions in the discovery and development of new medicinal entities.

In 21 chapters, this book highlights chemistry and pharmaceutical potential of natural products in modern drug discovery processes, and covers the synthesis and semi-synthesis of potentially bioactive natural products. Written for phytochemists, synthetic chemists, combinatorial chemists, as well as other practitioners and students in related fields, the book features chemical advances in naturally occurring organic compounds and describes their chemical transformations and structure–activity relationships.

Table of Contents

Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds
Goutam Brahmachari
Impact of Solid-Supported Cyclization–Elimination Strategies toward the Development of Natural Product Inspired Molecules in Drug Discovery Research
Dhananjay Kumar, Bhuwan B. Mishra, Divya Kushwaha, and Vinod K. Tiwari
Synthesis and Biological Studies of Novel β-Lactams Bimal K. Banik
Applications of Isatin Chemistry in Organic Synthesis and Medicinal Chemistry
Girija S. Singh and Zelalem Y. Desta
Role of Organic Carbamates in Anticancer Drug Design
Devdutt Chaturvedi
Rational Design of New Molecules of Biological Significance from Phenolic Constituents of Some Tropical Plants as Renewable Materials
Vladimir V. Kouznetsov, Diego R. Merchan Arenas, Fernando A. Rojas Ruiz,
and Leonor Y. Vargas Méndez
Synthesis and Biological Activity of Promising Azole Marine Products: Largazole and Neopeltolide
Danilo Davyt and Gloria Serra
Omega-3 (ω-3) Polyunsaturated Fatty Acids Philip C. Calder
Structure and Biological Activity of Natural Melanin Pigments
Krystyna Stępień, Anna Dzierżęga-Lęcznar, Irena Tam, and Slawomir Kurkiewicz
Recent Acquisitions on Naturally Occurring Oxyprenylated Secondary Plant Metabolites
Francesco Epifano and Salvatore Genovese
Role of Curcumin in Ameliorating Neuroinflammation and Neurodegeneration Associated with Alzheimer’s Disease
Sumit Sarkar, Balmiki Ray, Jay Sharma, Larry Schmued, and Debomoy K. Lahiri
Plant Metabolites
Marina P. Polovinka and Nariman F. Salakhutdinov
X-Ray Structural Behavior of Some Significant Bioactive Steroids and Their Chemistry in the Crystal Packing and Related Matters
Vivek K. Gupta
Three-Dimensional Structure of Xanthones
Luís Gales and Ana M. Damas
Gambogic Acid
Goutam Brahmachari
Neuroplasticity as a New Approach to the Pathophysiology of Depression and the Role of Antidepressants in Inhibiting Brain Stress-Induced Changes
Gianluca Serafini, Maurizio Pompili, and Paolo Girardi
Statins
Vincent Gullo and Arnold L. Demain
Molecular Aspects of Fungal Bioactive Polyketides
Ira Bhatnagar and Se-Kwon Kim
Marine Microalgal Metabolites
S.W.A. Himaya and Se-Kwon Kim
Rosmarinic Acid
Juan C. Luis, Maria Y. González-Padrón, Raquel M. Pérez, Ignacio F. Viera, and Francisco V. González
Enhancement of Natural Antioxidants in Plants by Biosynthetic Pathway Modulation
Kanakapura K. Namitha and Pradeep S. Negi
Plant as Biofactories of Pharmaceuticals and Nutraceuticals
Dandara R. Muniz, Raquel de Oliveira Faria, Vagner Augusto Benedito, Ângelo de Fátima, and Luzia Valentina Modolo

Editor Bio(s)

Goutam Brahmachari, Ph.D. is an Associate Professor within the Laboratory of Natural Products and Organic Synthesis, Department of Chemistry, at Visva-Bharati University, India.

Editorial Reviews

"This title is of immense interest to researchers in the life sciences …[T]he book does provide more than 550 pages of information in 21 chapters focused on various compounds or classes thereof…In summary, most chapters of the book are well founded scientifically, with descriptions of recent research advances."

—John Thor Arnason, PhD, director of biopharmaceutical sciences, University of Ottawa, Ontario, Canada, in HerbalGram, The Journal of the American Botanical Council