Nutrigenomics and Nutrigenetics in Functional Foods and Personalized Nutrition

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Features

  • Emphasizes methods of bringing nutrigenomics and nutrigenetics to the food industry, health professionals, and the public
  • Brings together contributions by key players in the field, edited by a well-respected researcher
  • Explores how nutrigenomics and nutrigenetics can help modify disease risk in cardiovascular disease, obesity, diabetes, and inflammatory bowel disease
  • Presents several technologies in nutrigenetics and nutrigenomics, including data mining and network analysis, transcriptomic analysis, proteomic analysis, metabolomics, and bioinformatics
  • Addresses regulatory issues such as genetic testing and the role of science in the commercialization of nutrigenomics

Summary

While functional foods have become a reasonably well-established concept, personalized nutrition is still treated with skepticism by many. The recognition that people would have different nutrient requirements, or perceive foods in different ways, raises several concerns—some real, some not so real. Nutrigenomics and Nutrigenetics in Functional Foods and Personalized Nutrition addresses what is needed to bring nutrigenomics, nutrigenetics, and their associated technologies to market in a truly impactful way.

Edited by Lynnette R. Ferguson, a well-known and internationally respected researcher, the book covers a wide range of issues, from the purely scientific to ethical, consumer-driven, and public health aspects. It takes a close look at gene–diet interactions and explores the ways in which studies on nutrigenomics and nutrigenetics can help modulate disease risk in cardiovascular disease, obesity, diabetes, and inflammatory bowel disease. Topics include regulatory challenges, genetic testing for consumers, data mining, transcriptomic analysis, and the role of science and health professionals in the commercialization of nutrigenomics and nutrigenetics. The book also examines industry–academia partnerships as a nexus between the science and its commercialization by the food industry. These partnerships will be an important determinant of what value the technologies bring, not only to the market but to the wider health and well-being of society.

Exploring how nutrigenomics and nutrigenetics can help modulate disease risk, this timely book brings together stimulating, well-thought-out perspectives from established and emerging researchers. It provides valuable information on a subject that is becoming increasingly important for nutritionists, dieticians, and clinical professionals, as well as for the food industry and research community.

Table of Contents

Examples of Some Key Gene-Diet Interactions

Nutrigenetics and Nutrigenomics: Importance for Functional Foods and Personalized Nutrition
Lynnette R. Ferguson

Variations in Solute Transporter Genes Affecting Micronutrient Solute Transport and Human Health
Peter Eck

Genetic Variants in the Omega-6 and Omega-3 Fatty Acid Metabolic Pathway: Their Role in the Determination of Nutritional Requirements and Chronic Disease Risk
Artemis P. Simopoulos

Nutrigenomic Approaches to Unraveling the Physiological Effects of Complex Foods
Peter J. Gillies and John P. Vanden Heuvel

Modifying Disease Risk through Nutrigenetics and Nutrigenomics

Modulating the Risk of Cardiovascular Disease through Nutrigenetics
Antonio Garcia-Rios, Javier Delgado-Lista, Pablo Perez-Martinez, Francisco Pérez-Jimenez, and Jose Lopez-Miranda

Modulating the Risk of Obesity and Diabetes through Nutrigenetics
Helen M. Roche and Catherine Phillips

Nutrigenetics and Crohn’s Disease
Lynnette R. Ferguson

Microbiome and Host Interactions in Inflammatory Bowel Diseases: Relevance for Personalized Nutrition
Wayne Young, Bianca Knoch, and Nicole C. Roy

Importance of Cell-Specific Gene Expression Patterns for Understanding Nutrient and Gene Interactions in Inflammatory Bowel Diseases
Anna E. Russ, Jason S. Peters, Warren C. McNabb, and Nicole C. Roy

Technologies in Nutrigenetics/Nutrigenomics

Data Mining and Network Analysis: Potential Importance in Nutrigenomics Research
Vijayalakshmi Varma and Jim Kaput

Metabolomics: An Important Tool for Assessing State of Health and Risk of Disease in Nutrigenomics Research
Hui-Ming Lin and Daryl Rowan

Epigenetics—What Role Could This Play in Functional Foods and Personalised Nutrition?
Matthew P.G. Barnett, Shalome A. Bassett, and Emma N. Bermingham

Foodomics to Study Efficacy of Human Dietary Interventions: Proof of Principle Study
Stephanie Ellett, Isobel R. Ferguson, Shuotun Zhu, Nishi Karunasinghe, Gareth Marlow, Daniel Hurley, Wen J. Lam, Dug Y. Han, and Lynnette R. Ferguson

Considerations in Estimating Genotype in Nutrigenetic Studies
Angharad R. Morgan

Bringing Nutrigenomics to Industry, Health Professionals, and the Public

Bringing Nutrigenomics to the Food Industry: Industry–Academia Partnerships as an Important Challenge
Ralf C. Schlothauer and Joerg Kistler

Commercialization and Potential of Nutrigenetics and Nutrigenomics
Virginia Parslow and Lynnette R. Ferguson

Bringing Nutrigenomics to the Public: Is Direct-to-Consumer Testing the Future of Nutritional Genomics?
David Castle

Nutritional Genomics in Practice: Interaction with Health Professionals in Bringing Nutritional Genomics to the Public
Colleen Fogarty Draper

Harvesting Normative Potential for Nutrigenomic Research
Bart Penders and Michiel Korthals

Public Health Context for Nutrigenomics and Personalized Nutrition
Elizabeth H. Marchlewicz, Karen E. Peterson, and Gilbert S. Omenn

Nutrigenomics and Public Health
Maria Agelli and John A. Milner

Index

Editor Bio(s)

Lynnette R. Ferguson, D.Phil., D.Sc., QSO, FNZIFST, works at the Auckland Cancer Society Research Centre, using mutagenicity testing as a predictor of carcinogenesis. In 2000, she also took on a 50 percent role as head of the Nutrition Department at the University of Auckland. Her research interests include the interplay between genes and diet in the development of chronic disease, with particular focus on inflammatory bowel disease, a cancer-prone condition, and also in prostate cancer. As program leader for the multidisciplinary-multiorganization Nutrigenomics New Zealand, she is working to bring nutrigenomics tools and potential to the New Zealand science scene. She is the author or coauthor of more than 300 peer-reviewed publications, including chapters in books and articles in international journals. She serves as one of the managing editors for Mutation Research: Fundamental and Molecular Mechanisms of Mutation and is on the editorial boards of several other major journals.