Chemotherapy-Induced Neuropathic Pain

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ISBN 9781439862186
Cat# K12881



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Cat# KE13053



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  • Addresses the issues of chemotherapy-induced neuropathic pain
  • Covers basic science and clinical research
  • Explains the physiology of normal and neuropathic pain
  • Describes the effect of various cytotoxic agents on different nerves
  • Provides insight into drug discovery efforts
  • Explores practical pain management strategies, tactics, and options


There have been tremendous recent advances in the pharmacotherapy, dose regimens, and combinations used to treat cancer and for the treatment or prevention of the spread of disease. As a direct result of these advances, there are an increasing number of cancer survivors, although research dealing with chemotherapy-induced pain is still in its early years.

Written for pain management specialists, oncologists, pharmacologists, students, and primary care practitioners, Chemotherapy-Induced Neuropathic Pain provides insight into the important area of chemotherapy-induced neuropathic pain. It reviews the basic and clinical research into the normal physiology of pain transmission pathways, neuropathic pain pathology, the chemotherapeutic drug mechanisms of action and adverse effects, chemotherapy-induced neuropathy, and drug discovery efforts for treatment.

The contributors comprise an impressive list of clinical and basic science experts in the fields of pain mechanisms and pain management. Included are clinical directors of pain clinics and clinical research facilities, directors of large academic pain research laboratories, analgesic drug developers, and presidents of the International Association for the Study of Pain (IASP), Association of Chronic Pain Patients (ACPP), and the British Pain Society (BPS). Through them, the book provides the reader with an exceptional opportunity to acquire a fundamental understanding of the basic concepts related to this topic.

Table of Contents

Chemotherapy-Induced Neuropathic Pain: Clinical Features
Michael Husband and Richard Langford
Assessment and Grading of Cancer Chemotherapy-Induced Neuropathic Pain
Judith A. Paice
Chemotherapy-Induced Peripheral Neuropathy: Review of Clinical Studies
Jo Ann LeQuang and Joseph Pergolizzi
Orofacial Neuropathy and Pain in Cancer Patients
Yehuda Zadik, Noam Yarom, and Sharon Elad
Cancer Chemotherapy-Induced Neuropathic Pain: The Underlying Peripheral Neuropathy
Robert B. Raffa and Joseph V. Pergolizzi, Jr.
Bedside to Bench: Research on Chemotherapy-Induced Neuropathic Pain
Haijun Zhang, Juan P. Cata, and Patrick M. Dougherty
In Vivo
Models and Assessment of Pharmacotherapeutics for Chemotherapy-Induced Neuropathic Pain
Sara Ward
Drug Treatment for Chemotherapy-Induced Neuropathic Pain: Amitriptyline as an Example
Eija Kalso
Experimental Design and Analysis of Drug Combinations Applicable to Chemotherapy-Induced Neuropathic Pain
Ronald J. Tallarida
Central Neuromodulation for Chemotherapy-Induced Neuropathic Pain
Helena Knotkova, Dru Nichols, and Ricardo A. Cruciani
Nerve Decompression for Chemotherapy-Induced Neuropathic Pain
Michael I. Rose

Editor Bio(s)

Robert B. Raffa, Ph.D. is Professor and Chair within the Department of Pharmaceutical Sciences at Temple University School of Pharmacy, in Philadelphia, Pennsylvania.

Ronald J. Tallarida, Ph.D. is Professor of Pharmacology at Temple University School of Medicine in Philadelphia, Pennsylvania.

Frank Porreca, Ph.D. is Professor of Pharmacology and Anesthesiology at Temple University in Philadelphia, Pennsylvania.

Joseph V. Pergolizzi, Jr., M.D. is Adjunct Assistant Professor at Johns Hopkins University School of Medicine in Baltimore, Maryland.