1st Edition
Computational Methods for Reproductive and Developmental Toxicology
Building from the perspective of reproductive and developmental biology, Computational Methods for Reproductive and Developmental Toxicology provides a timely and comprehensive overview of approaches in reproductive and developmental toxicology.
The book, which is part of the QSAR in Environmental and Health Sciences series, is divided into three broad sections. The first provides a review of methods and approaches to meet the need for safety assessments in product development and regulatory approaches for environmental chemicals. The next one reviews the biological processes and endpoints involved in reproduction and development.
The final and largest section summarizes protocols for evaluating biological processes and endpoints within reproduction and development. It also discusses informatics resources and computational methods.
The book takes a cross-disciplinary approach bringing together developmental, reproductive and systems biology, chemistry, toxicology, pharmacology, biostatistics, information sciences, bioinformatics, and computational approaches. This valuable resource provides those in the field with the necessary knowledge to evaluate both classic and recent approaches to characterize toxicity.
INTRODUCTION
Introduction
Donald R. Mattison
Visions and Advancements for Meeting the Needs of Safety Assessment of Pharmaceutical and Industrial Chemicals
Karen A. Augustine-Rauch
REACH and Environmental Chemicals
Olivier Taboureau, Karine Audouze, and Søren Brunak
REPRODUCTION AND DEVELOPMENT: BIOLOGICAL PROCESSES AND ENDPOINTS
Female Reproductive Physiology
Mariangela Maluf and Paulo Marcelo Perin
Maternal Recognition of Pregnancy
Paulo Marcelo Perin and Mariangela Maluf
Early Embryo Development and Bipotential Gonad Formation
Paulo Marcelo Perin and Mariangela Maluf
Assessing the Reproductive Health of Men with Occupational Exposures
Steven M. Schrader, Susan Reutman, and Katherine L. Marlow
REPRODUCTION AND DEVELOPMENT: BIOLOGICAL AND COMPUTATIONAL METHODS
Animal Study Protocols and Alternative Assays for the Assessment of Reproductive and Developmental Toxicity
Aldert H. Piersma
US National Library of Medicine Resources for Computational Toxicology
Pertti J. Hakkinen
Modeling Endocrine Regulation of the Menstrual Cycle Using Delay Differential Equations
Leona A. Harris and James F. Selgrade
Molecular Structural Characteristics That Influence Partitioning of Xenobiotics into Human Breast Milk
Snezana Agatonovic-Kustrin and David W. Morton
Approaches for Pediatric Developmental Drug-Induced Liver Injury
William F. Salminen and Xi Yang
Adverse Outcome Pathways for Developmental Toxicity
Damiano Portinari and Philip N. Judson
Biography
Edited by
Donald R. Mattison, National Institutes of Health, Bethesda, Maryland, USA, and Risk Sciences International, Ottawa, Ontario, Canada