Introduction to Natural Products Chemistry

Introduction to Natural Products Chemistry

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Summary

Natural products chemistry—the chemistry of metabolite products of plants, animals and microorganisms—is involved in the investigation of biological phenomena ranging from drug mechanisms to gametophytes and receptors and drug metabolism in the human body to protein and enzyme chemistry.

Introduction to Natural Products Chemistry has collected the most important research results of natural product chemistry in China. It overviews the basic principles of isolation, structure, and characteristics of natural products and illustrates current research techniques of structure elucidation with real-life examples of wet chemistry and spectroscopic analyses (UV, IR, MS, and NMR, especially 2d-NMR, HMBC, and HMQC), bioactivity, biosynthesis, and chemical synthesis.

Specifically, this book covers:

  • Extraction and isolation of natural products
  • Chemistry of fungal products
  • Alkaloids, sesquiterpenoids, diterpenes, and saponins
  • Amino acids and peptides
  • Flavonoids, anthraquinones, coumarins, and lignans
  • Marine natural products
  • Structural modification of active principles from traditional Chinese medicine
  • Chemical synthesis of natural products

Although natural products chemistry has produced enormous results and made great contributions to human health, industry, and agriculture, only a fraction of natural resources have been rigorously studied. Chinese natural products are a gold mine for further exploration with modern technology and methods. This book represents the continuing collaboration between the fields of natural products chemistry, medicine, biology, and agriculture which will continue to discover and implement novel chemical products from natural sources.

Table of Contents

Introduction, Ren-Sheng Xu

Extraction and Isolation of Natural Products
. Ren-Sheng Xu
Extraction of Natural Products
Separation of Natural Products
Concluding Remarks
Bibliography
References

Chemistry of Fungal Products,
Zhi-Hong Xu
Introduction
Bioactive Fungal Metabolites
Mycotoxins from Fungi
Isolation and Structure Studies of Fungal Products
Perspectives
References

Alkaloids,
Ren-Sheng Xu and Yang Ye
General
Characterization, Identification and Isolation
Classification
Structural Investigations of Some Alkaloids
Bibliography
References

Sesquiterpenoids,
Zhong-Liang Chen
Chemical Properties, Isolation and Purification
Spectroscopic Analysis of Sesquiterpenes
Artemisinin - Chemistry, Pharmacology, and Clinical Uses
Recent Progress of Specific Sesquiterpenes
References

Diterpenes,
Zhi-DaMin
Main Diterpene Skeletons
Biogenesis
Labdanes
Clerodanes
Pimaranes
Abietanes
Cassanes and Totaranes
Taxanes
Tiglianes, Ingenanes and Daphnanes
Jatrophanes and Lathyranes
Myrsinols and Euphorsctines
Ginkgolides and Pseudolaric Acid
References

Saponins,
Wei-Min Zhao
Introduction
Extraction and Isolation of Saponins
Structure Determination of Saponins
Biological Activity of Saponins
Triterpenoid Saponin
Steroidal Saponins
Bibliography
References

Amino Acids and Peptides,
Chang-Qi Hu and Jie-Cheng Xu
Amino Acids
Peptides
References

Flavonoids,
De-Yun Kong
Overview
Extraction and Isolation of Flavonoids
Identification and Structure Study of Flavonoids
Pharmacological Study of Flavonoids
Flavonoids Assay Determination and Formulation
Conclusion
References

Anthraquinones,
Yang Lu
Introduction
Physical and Chemical Properties
Extraction and Isolation
Spectral Characteristics
Examples
References

Coumarins,
Ze-Nai Chen
Introduction
Structural Types
Physical and Chemical Properties
Isolation
Spectroscopic Identification
Research Example
References

Lignans,
Chang-Qi Hu
Introduction
Structural Types and Characteristics of Lignans
Bioactivities of Lignans
References

Other Natural Bioactive Compounds,
Ren-Seng Xu
Sulfur Compounds
Cyanide Compounds
Coixenolide
Resveratrol
Muscone
Cardiac Glycosides
Bibliography
References

Marine Natural Products,
Yue-Wei Guo and Wen Zhang
Introduction
Marine Plants
Marine Invertebrates
Marine Microorganisms and Phytoplankton
Miscellaneous
Examples
Epilogue (Outlook)
References

Structural Modification of Active Principles from TCM,
Da-Yuan Zhu
Introduction
Anti-malaria Drug Arthemether
Anti-hepatitis Drug Bifendate
Anti-AD Drug Huperzine A
Antiarrhythmia Drug Changrolin
Antineoplastic Drugs
Computer-Aided Drug Design
References

Chemical Synthesis of Natural Products,
Wen-Hu Duan
Alkaloids
Terpene
Flavonoids
Synthesis of Anthraquinones
Lignans
Synthesis of Macrolide Antibiotics
Bibliography
References