Vibrational Spectroscopy for Tissue Analysis

Vibrational Spectroscopy for Tissue Analysis

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Features

  • Presents biological applications of vibrational spectroscopy
  • Provides definitions and characterization of peak frequencies and other aspects of spectroscopy
  • Includes a unique database of up-to-date data on tissue Raman and FTIR spectroscopy
  • Reflects the authors’ hands-on experience with a variety of applications

Summary

A rapidly growing field, vibrational spectroscopy has found applications in industries including pharmaceutical manufacture, food and drug safety, and process monitoring on production lines. In particular, interest in clinical spectroscopy is rising rapidly as researchers recognize the potential of the vibrational spectroscopic techniques—Infrared (IR) and Raman Spectroscopy—as noninvasive tissue diagnosis tools. However, the details of the characteristic peak frequencies and their relationship to specific functional groups present in the biological tissues have not been fully understood.

Vibrational Spectroscopy for Tissue Analysis introduces IR and Raman Spectroscopy to those scientists who are either using these spectroscopic techniques to address clinical problems or planning to use spectroscopy to analyze clinical tissues and understand their chemical composition. By compiling the interpretations and understandings of the spectral peaks of the biological molecules in one place, this book aids in the understanding of IR and Raman Spectroscopy, and what these techniques can offer both in early diagnosis of the disease and monitoring of the progression of the disease.

Despite the tremendous advances in the field of spectroscopy, where new applications are emerging at the pace of development, there are still areas of research that are crying for further exploration. This book bridges the gap between the spectroscopic research and medical applications.

Table of Contents

Introduction to Spectroscopy
History
Regions of the Spectrum
FTIR and Dipole Moment Change
FTIR and Raman Spectrometry
References

Spectroscopy and Molecular Changes in Cancer Cells
Introduction
Understanding Cancer
Peak Assignments of Biological Molecules
References

The Biology of Cancer
Epidemiology of Cancer
Cancer Development
Causes of Cancer
Mechanisms in Generation of Tumors
Oncogenes
Tumour Suppressor Genes
Possible Functions of Tumour Suppressor Genes
The Cell Cycle
Phases of the Cell Cycle
Regulation of the Cell Cycle
Properties of Cancerous Cells
Disordered Mechanisms in Malignant Cells
References

Vibrational Spectroscopy and Cancer
Introduction
Skin Cancer
Head and Neck Cancer
Other Biological Molecules
Breast Cancer
Cervical and Ovarian Cancers
Adenocarcinoma
Epithelial Cancer
Lung Cancer
Breast Cancer
Skin Cancer
Gastrointestinal Cancer
Colon Cancer
Oesophageal Cancer
Stomach Cancer
Pancreatic Cancer
Gastric Cancer
Brain Tissues
Oral Squamous Cell Carcinoma
Nasopharyngeal Carcinoma
Blood-Related Tissue and Organs
FTIR Spectroscopy for Cancer Grading
Prostate Cancer
Colon Cancer
Investigating Cell Lines
Analysing Saliva
Other Spectroscopic Studies
Summary
References

FTIR and Raman Spectroscopy and Imaging of Breast Cancer
Introduction
Materials and Methods
Analysis of Cancerous Tissues Using FTIR Rapid Scan Imaging
Summary
Future Work
References

Detecting and Monitoring of Cancer at the Cellular Level
Introduction
Analysis of Resistant and Sensitive Subtypes of Testicular Cancer Cell Lines Quantitative Analysis of the Spectra of 833k Samples
Treated Cell Lines
Other Testicular Cell Lines
Summary
Acknowledgements
References

Chemical Structural Analysis of Bone by Spectroscopy
Introduction
Raman Spectroscopy of Bone
Comparison of Natural and Synthetic Apatites
Infrared Spectroscopy of Bone
FTIR Spectral Data Acquisition and Analysis
Summary
References

FTIR and Raman Characteristic Peak Frequencies in Biological Studies
Introduction
Characteristic Peak Frequencies
Summary
References

Future Potential Clinical Applications of Spectroscopic Techniques in Human Diseases
Diagnosis
Determination of Prognostic Factors
Determination of Extent of Disease Process
Designing Therapy and Guiding Tissue Biopsy
Evaluating Efficacy and Response to Treatment
Earlier Detection of Recurrence and Metastases
Detection of Tissue Injury
Detection of Therapeutic Drug Levels
References

Author Bio(s)

Ihtesham Ur Rehman is a reader in biomedical materials at Queen Mary, University of London, UK.

Zanyar Movasaghi is a doctor of dental surgery at Queen Mary, University of London, UK.

Shazza Rehman is a consultant in medical oncology with St. George’s Healthcare NHS Trust.

 
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