Topical Nail Products and Ungual Drug Delivery

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ISBN 9781439811290
Cat# K10565



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ISBN 9781439811313
Cat# KE10527



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  • Represents the seminal work on ungual and trans-ungual drug delivery
  • Overviews of the properties of the nail, its permeability, available formulations, and future concepts
  • Provides the most up-to-date information on ex vivo models of trans-ungual drug delivery
  • Covers ongoing research on physical and chemical techniques of drug permeation enhancement and novel techniques
  • Includes color and greyscale illustrations to show various diffusion cell models, ex vivo models, and procedures


Discussing existing techniques, ongoing research, new approaches, and basic concepts in the treatment of nail diseases, Topical Nail Products and Ungual Drug Delivery summarizes the current knowledge and represents a jumping-off point for creating novel techniques of drug delivery across the nail.

A growing area of pharmaceutical research, the search for efficient delivery techniques that can cross the nail barrier has yielded several effective strategies, brought together in this book.

Topics Include

  • Nail anatomy, physiology, diseases, and treatment
  • Permeability of the nail plate
  • Topical nail formulations
  • Approaches to enhance ungual and trans-ungual drug delivery
  • In vitro and in vivo models to evaluate topical nail formulations
  • Nail sampling techniques
  • Bioengineering of the nail
  • Trans-ungual iontophoresis
  • Pharmacokinetics of drugs in the nail apparatus
  • Onychopharmacokinetics: proposed model insight
  • Photodynamic therapy of nail diseases
  • The nail as a surrogate for investigating drug use

Table of Contents

The Nail: Anatomy, Physiology, Diseases, and Treatment
Sudaxshina Murdan
Permeability of the Nail Plate
Jinsong Hao and Kevin S. Li
Topical Nail Formulations
H. N. Shivakumar, Michael A. Repka, Sudaxshina Murdan and S. Narasimha Murthy
Approaches to Enhance Ungual and Trans-Ungual Drug Delivery
H. N. Shivakumar, Abhishek Juluri, Michael A. Repka, and S. Narasimha Murthy
In Vitro and In Vivo Models to Evaluate Topical Nail Formulations
Anroop B. Nair, Xiaoying Hui, Majella E. Lane, and S. Narasimha Murthy
Hydration-Controlled Nail System for the Evaluation of Topical Formulations and a Novel Nail Sampling Device
Rania Elkeeb, Xiaoying Hui, and Howard I. Maibach
Bioengineering of the Nail: Transonychial Water Loss and Imaging Techniques, An Overview
Rania Elkeeb and Howard I. Maibach
Transungual Iontophoresis and Physical Drug Delivery Enhancement
Jinsong Hao and Kevin S. Li
Pharmacokinetics of Drugs in the Nail Apparatus
Danièle Debruyne and Antoine Coquerel
Onychopharmacokinetics: Proposed Model Insight
Rania Elkeeb, Xiaoying Hui, Laila Elkeeb, Ali Ali-Khan, and Howard I. Maibach
Photodynamic Therapy of Nail Diseases
Ryan F. Donnelly, Corona M. Cassidy, and Michael M. Tunney
Nail as a Surrogate for Investigating the Drug Use
Katarzyna Madej

Author Bio(s)