Polymeric Biomaterials: 2 Volume Set, Third Edition

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ISBN 9781420094725
Cat# 94726



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  • Updated and expanded into a comprehensive new edition containing 53 chapters in two volumes: Structure and Function and Medicinal and Pharmaceutical Applications
  • Reflects the current state of knowledge of nearly the entire spectrum of polymeric biomaterials
  • Provides the most up-to-date coverage of key new materials and their properties, such as synthetic fibers as biomaterials and metal–polymer composites
  • Presents new application chapters including Modular Biomimetic Drug Delivery Systems, Biomedical Applications of Shape Memory Polymers and Their Nanocomposites, Polymeric Gene Delivery Carriers for Pulmonary Diseases, and Bioceramics for Development of Bioartificial Liver
  • Written by world-renowned scientists with major contributions in the field of biomaterials


Biomaterials have had a major impact on the practice of contemporary medicine and patient care. Growing into a major interdisciplinary effort involving chemists, biologists, engineers, and physicians, biomaterials development has enabled the creation of high-quality devices, implants, and drug carriers with greater biocompatibility and biofunctionality. The fast-paced research and increasing interest in finding new and improved biocompatible or biodegradable polymers has provided a wealth of new information, transforming this edition of Polymeric Biomaterials into a two-volume set. Completely revised and expanded, this state-of-the-art reference presents recent developments in polymeric biomaterials: from their chemical, physical, and structural properties to current applications in the medical and pharmaceutical fields.

The book is organized into two volumes containing 53 authoritative chapters written by experts from around the world. The first volume, Polymeric Biomaterials: Structure and Function, contains information about the structure and properties of synthetic polymers including polyesters, polyphosphazenes, and elastomers and natural polymers such as mucoadhesives, chitin, lignin, and carbohydrate derivatives. It also describes their blends or composites—for example, metal–polymer composites and biodegradable polymeric/ceramic composites—as well as drug carriers and delivery systems, gene and nucleic acids delivery, and polymer synthesis and processing techniques.

The second volume, Polymeric Biomaterials: Medicinal and Pharmaceutical Applications, addresses processing of polymeric biomaterials into specific forms that ensure biocompatibility and biodegradability for various uses in the medical and pharmaceutical arenas. The chapters address numerous medical issues including pulmonary disease, cancer, heart disease, tissue damage, and bone disease. The applications covered include a variety of drug delivery systems, medical devices, anticancer therapies, biological uses for hydrogels, nanotechnology, bioartificial organs, and tissue engineering. This third edition set presents new and substantially revised topics, providing a comprehensive reference of the latest developments and the most up-to-date applications of biomaterials in medicine.

Table of Contents

Volume 1:

Synthesis and Fabrication of Polyesters as Biomaterials
Philippe Lecomte and Christine Jérôme

Hydrogels Formed by Cross-Linked Poly(Vinyl Alcohol)
Gaio Paradossi

Development and Evaluation of Poly(Vinyl Alcohol) Hydrogels as a Component of Hybrid Artificial Tissues for Orthopedics Surgery Application
Masanori Kobayashi

Polyphosphazenes as Biomaterials
Meng Deng, Cato T. Laurencin, Harry R. Allcock, and Sangamesh G. Kumbar

Biodegradable Polymers as Drug Carrier Systems
Abraham J. Domb and Wahid Khan

Bioresorbable Hybrid Membranes for Bone Regeneration
Akiko Obata and Toshihiro Kasuga

Mucoadhesive Polymers: Basics, Strategies, and Future Trends
Andreas Bernkop-Schnürch

Biodegradable Polymeric/Ceramic Composite Scaffolds to Regenerate Bone Tissue
Catherine Gkioni, Sander Leeuwenburgh, and John Jansen

Amphiphilic Systems as Biomaterials Based on Chitin, Chitosan, and Their Derivatives
Jacques Desbrieres

Biomaterials of Natural Origin in Regenerative Medicine
Vijay Kumar Nandagiri, Valeria Chiono, Piergiorgio Gentile, Franco Maria Montevecchi, and Gianluca Ciardelli

Natural Polymers as Components of Blends for Biomedical Applications
Alina Sionkowska

Metal–Polymer Composite Biomaterials
Takao Hanawa

Evolution of Current and Future Concepts of Biocompatibility Testing
Menno L.W. Knetsch

Biocompatibility of Elastomers
Dominique Chauvel-Lebret, Pascal Auroy, and Martine Bonnaure-Mallet

Preparation and Applications of Modulated Surface Energy Biomaterials
Blanca Vázquez, Luis M. Rodríguez-Lorenzo, Gema Rodríguez-Crespo, Juan Parra, Mar Fernández, and Julio San Román

Electrospinning for Regenerative Medicine
Toby D. Brown, Cedryck Vaquette, Dietmar W. Hutmacher, and Paul D. Dalton

Polymeric Nanoparticles for Targeted Delivery of Bioactive Agents and Drugs
Cesare Errico, Alberto Dessy, Anna Maria Piras, and Federica Chiellini

Polymeric Materials Obtained through Biocatalysis
Florin Dan Irimie, Csaba Paizs, and Monica Ioana Tosa

Polymer-Based Colloidal Aggregates as a New Class of Drug Delivery Systems
Cesare Cametti

Photoresponsive Polymers for Control of Cell Bioassay Systems
Kimio Sumaru, Shinji Sugiura, Toshiyuki Takagi, and Toshiyuki Kanamori

Lignin in Biological Systems
Valentin I. Popa

Carbohydrate-Derived Self-Crosslinkable In Situ Gelable Hydrogels for Modulation of Wound Healing
Lihui Weng, Christine Falabella, and Weiliam Chen

Dental and Maxillofacial Surgery Applications of Polymers
E.C. Combe

Biomaterials as Platforms for Topical Administration of Therapeutic Agents in Cutaneous Wound Healing
Rhiannon Braund and Natalie J. Medlicott

Polymers for Artificial Joints
Masayuki Kyomoto, Toru Moro, and Kazuhiko Ishihara

Volume 2:

Antithrombin–Heparin Complexes
Leslie R. Berry and Anthony K.C. Chan

Glucose-Sensitive Hydrogels
Seong Hoon Jeong, Kyung T. Oh, and Kinam Park

Advances in Polymeric and Lipid-Core Micelles as Drug Delivery Systems
Tiziana Musacchio and Vladimir P. Torchilin

Modular Biomimetic Drug Delivery Systems
Carmen Alvarez-Lorenzo, Fernando Yañez- Gomez, and Angel Concheiro

Polymeric Nanoparticles for Drug Delivery
Karine Andrieux, Julien Nicolas, Laurence Moine, and Gillian Barratt

Drug Carrier Systems for Anticancer Agents
Hiroyuki Koide, Tomohiro Asai, Kosuke Shimizu, and Naoto Oku

Application of Polymer Drugs to Medical Devices and Preparative Medicine
M.R. Aguilar, L. García-Fernández, M.L. López-Donaire, F. Parra, L. Rojo, G. Rodríguez, M.M. Fernández, and J. San Román

Polymer Implants for Intratumoral Drug Delivery and Cancer Therapy
Brent D. Weinberg and Jinming Gao

Biological Stimulus-Responsive Hydrogels
A.K. Bajpai, Sanjana Kankane, Raje Chouhan, and Shilpi Goswami

Polymeric Materials for Surface Modification of Living Cells
Yuji Teramura, Hao Chen, Naohiro Takemoto, Kengo Sakurai, and Hiroo Iwata

Biomedical Applications of Shape Memory Polymers and Their Nanocomposites
I. Sedat Gunes and Sadhan C. Jana

Bioadhesive Drug Delivery Systems
Ryan F. Donnelly and A. David Woolfson

Nanomedicines Coming of Age
Radoslav Savic, Jinzi Zheng, Christine Allen, and Dusica Maysinger

Polymers for Myocardial Tissue Engineering
J.A. Roether, H. Jawad, R. Rai, N.N. Ali, S.E. Hardling, and A.R. Boccaccini

Acellular Tubular Grafts Constructed from Natural Materials in Vascular Tissue Engineering
M.J.W. Koens, A.G. Krasznai, J.A. van der Vliet, T. Hendriks, R.G. Wismans, K.A. Faraj, W.F. Daamen, and T.H. van Kuppevelt

pH-Responsive Polymers for Delivery of Nucleic Acid Therapeutics
Yu Nie and Ernst Wagner

Adhesive Biomaterials for Tissue Repair and Reconstruction
Sujata K. Bhatia

Polymeric Interactions with Drugs and Excipients
James C. DiNunzio and James W. McGinity

Manufacturing Multifunctional Scaffolds for Tissue Engineering
Vincenzo Guarino, Antonio Gloria, Roberto De Santis, and Luigi Ambrosio

Virus-Based Nanoparticles as Drug Delivery Systems
Eva Roblegg and Andreas Zimmer

Polymeric Biomaterials in Pulmonary Drug Delivery
Nicole A. Beinborn and Robert O. Williams III

Polymeric Gene Delivery Carriers for Pulmonary Diseases
Xiang Gao, Regis R. Vollmer, and Song Li

Biomedical Application of Membranes in Bioartificial Organs and Tissue Engineering
Thomas Groth, Xiao-Jun Huang, and Zhi-Kang Xu

Controlled Release Systems for Bone Regeneration
Hossein Hosseinkhani

Controlled Release Systems Targeting Angiogenesis
Stéphanie Deshayes, Karine Gionnet, Victor Maurizot, and Gérard Déléris

Bioceramics for Development of Bioartificial Liver
Tomokazu Matsuura and Mamoru Aizawa

Materials Biofunctionalization for Tissue Regeneration
Laura Cipolla, Laura Russo, Nasrin Shaikh, and Francesco Nicotra

Polymers-Based Devices for Dermal and Transdermal Delivery
Donatella Paolino, Margherita Vono, and Felisa Cilurzo

Editor Bio(s)

Severian Dumitriu (deceased) was a research professor in the Department of Chemical Engineering at the University of Sherbrooke, Quebec, Canada. He edited several books, including Polymeric Biomaterials, Second Edition, Polysaccharides in Medicinal Applications, and Polysaccharides: Structural Diversity and Functional Versatility. He also authored or coauthored more than 190 professional papers and book chapters in the fields of polymer and cellulose chemistry, polyfunctional initiators, and bioactive polymers and held 15 international patents. Professor Dumitriu received his BSc (1959) and MS (1961) in chemical engineering and his Ph.D. (1971) in macromolecular chemistry from the Polytechnic Institute of Jassy, Romania.

Valentin I. Popa earned his BSc and MSc in chemical engineering (1969) and Ph.D. in the field of polysaccharide chemistry (1976) from Polytechnic Institute of Iasi, Romania. He was awarded the Romanian Academy Prize for his contributions in the field of seaweed chemistry (1976). He has published more than 500 papers in the following fields: wood chemistry and biotechnology, biomass complex processing, biosynthesis and biodegradation of natural compounds, allelochemicals, bioadhesives, and bioremediation. Dr Popa is also the author or coauthor of 37 books or book chapters. He holds six patents and has been involved in many Romanian and European research projects as scientific manager. He is also a professor of wood chemistry and biotechnology at "Gheorghe Asachi" Technical University of Iasi, and editor-in-chief of Cellulose Chemistry and Technology.

Editorial Reviews

"This third edition set is a versatile and comprehensive book, presenting new and substantially revised topics, and combining the basic fundamentals of the field of biomaterials with the industrial applications. Thus, the book is a very useful tool for scientists, engineers, pharmacists and other experts from different disciplines, as well as for teachers, graduate and undergraduate students interested in this area."
—Diana Ciolacu, Cellulose Chem. Technol., 47 (5-6), 487-494 (2013)