Handbook of Biomedical Optics
Features
- Provides an in-depth introduction to the field, exploring applications for biomedical research, diagnosis, and therapy
- Includes the theory and fundamentals of each subject with the aim of accessibility to a wide, multidisciplinary readership
- Discusses advantages and disadvantages of various state-of-the-art techniques
- Introduces the principles of optics, lights sources, and irradiation, as well as basic concepts in tissue optics
- Covers spectroscopic methods, including tomographic imaging, microscopic imaging methods, molecular probe development, and phototherapy
Summary
Biomedical optics holds tremendous promise to deliver effective, safe, non- or minimally invasive diagnostics and targeted, customizable therapeutics. Handbook of Biomedical Optics provides an in-depth treatment of the field, including coverage of applications for biomedical research, diagnosis, and therapy. It introduces the theory and fundamentals of each subject, ensuring accessibility to a wide multidisciplinary readership. It also offers a view of the state of the art and discusses advantages and disadvantages of various techniques.
Organized into six sections, this handbook:
- Contains introductory material on optics and the optical properties of tissue
- Describes the various forms of spectroscopy and its applications in medicine and biology, including methods that exploit intrinsic absorption and scattering contrast; dynamic contrast; and fluorescence and Raman contrast mechanisms
- Provides extensive coverage of tomography from the microscopic (optical coherence tomography) to the macroscopic (diffuse optical tomography) to photoacoustic tomography
- Discusses cutting-edge translations to biomedical applications in both basic sciences and clinical studies
- Details molecular imaging and molecular probe development
- Highlights the use of light in disease and injury treatment
The breadth and depth of multidisciplinary knowledge in biomedical optics has been expanding continuously and exponentially, thus underscoring the lack of a single source to serve as a reference and teaching tool for scientists in related fields. Handbook of Biomedical Optics addresses this need, offering the most complete up-to-date overview of the field for researchers and students alike.
Table of Contents
Preface
David A. Boas, Constantinos Pitris, Nimmi Ramanujam
I. Background
Geometrical Optics
Ting-Chung Poon
Diffraction Optics
Colin Sheppard
Optics: Basic Physics
Raghuveer Parthasarathy
Light Sources, Detectors, and Irradiation Guidelines
Carlo Amadeo Alonzo, Malte C. Gather, Jeon Woong Kang, Giuliano Scarcelli, Seok-Hyun Yun
Tissue Optical Properties
Alexey N. Bashkatov, Elina A. Genina, Valery V. Tuchin
II. Spectroscopy and Spectral Imaging
Reflectance Spectroscopy
Sasha McGee, Jelena Mirkovic, Michael Feld
Multi/Hyper-Spectral Imaging
Costas Balas, Christos Pappas, George Epitropou
Light Scattering Spectroscopy
Le Qiu, Irving Itzkan, Lev T. Perelman
Broadband Diffuse Optical Spectroscopic Imaging
Bruce J. Tromberg, Albert E. Cerussi, So-Hyun Chung, Wendy Tanamai, Amanda Durkin
Near Infrared Diffuse Correlation Spectroscopy for Assessment of Tissue Blood Flow
Guoqiang Yu, Turgut Durduran, Chao Zhou, Ran Cheng, Arjun G. Yodh
Fluorescence Spectroscopy
Darren Roblyer, Richard A. Schwarz, Rebecca Richards-Kortum
Raman, SERS and FTIR Spectroscopy
Andrew J. Berger
III. Tomographic Imaging
Optical Coherence Tomography: Introduction and Theory
Yu Chen, Evgenia Bousie, Constantinos Pitris, James G. Fujimoto
Functional Optical Coherence Tomography in Preclinical Models
Melissa C. Skala, Yuankai K. Tao, Anjul M. Davis, Joseph A. Izatt
Optical Coherence Tomography: Clinical Applications
Brian D. Goldberg, Melissa J. Suter, Guillermo J. Tearney, Brett E. Bouma
Forward Models of Light Transport in Biological Tissue
Andreas H. Hielscher, Hyun Keol Kim, Alexander K. Klose
Inverse Models of Light Transport
Simon Arridge, Martin Schweiger, John C. Schotland
Laminar Optical Tomography
Sean A. Burgess, Elizabeth M. C. Hillman
Diffuse Optical Tomography using Continuous Wave and Frequency Domain Imaging Systems
Subhadra Srinivasan, Scott C. Davis, Colin M. Carpenter
Diffuse Optical Tomography: Time Domain
Juliette Selb, Adam Gibson
Photoacoustic Tomography and Ultrasound-Modulated Optical Tomography
Changhui Li, Chulhong Kim, Lihong V. Wang
Optical and Photoacoustic Molecular Tomography of Small Animals
Vasilis Ntziachristos
IV. Microscopic Imaging
Assesing Microscopic Structural Features Using Fourier-Domain Low Coherence Interferometry
Robert N. Graf, Francisco E. Robles, Adam Wax
Phase Imaging Microscopy: Beyond Darkfield, Phase and Differential Interference Contrast Microscopy
Chrysanthe Preza, Sharon V. King, Nicoleta M. Dragomir, Carol J. Cogswell
Confocal Microscopy
William C. Warger II, Charles A. DiMarzio, Milind Rajadhyaksha
Fluorescence Microscopy with Structured Excitation Illumination
Alexander Brunner, Gerrit Best, Roman Amberger, Paul Lemmer, Thomas Ach, Stefan Dithmar, Rainer Heintzmann, Christoph Cremer
Nonlinear Optical Microscopy for Biology and Medicine
Daekeun Kim, Heejin Choi, Jae Won Cha, Peter T. C. So
Fluorescence Lifetime Imaging Microscopy, Endoscopy and Tomography
James McGinty, Clifford Talbot, Dylan Owen, David Grant, Sunil Kumar, Neil Galletly, Bebhinn Treanor, Gordon Kennedy, Peter M. P. Lanigan, Ian Munro, Daniel S. Elson, Anthony Magee, Dan Davis, Gordon Stamp, Mark Neil, Christopher Dunsby, Paul W. M. French
Application of Digital Holographic Microscopy in Biomedicine
Christian Depeursinge, Pierre Marquet, Nicolas Pavillon
Polarized Light Imaging of Biological Tissues
Steven L. Jacques
V. Molecular Probe Development
Molecular Reporter Systems for Optical Imaging
Walter J. Akers, Samuel Achilefu
Nanoparticles for Targeted Therapeutics and Diagnostics
Timothy Larson, Kort Travis, Pratixa Joshi, Konstantin Sokolov
Plasmonic Nanoprobes for Biomolecular Diagnostics of DNA Targets
Tuan Vo-Dinh, Hsin-Neng Wang
VI. Phototherapy
Photodynamic Therapy
Jarod C. Finlay, Keith Cengel, Theresa M. Busch, Timothy C. Zhu
Low Level Laser and Light Therapy
Ying-Ying Huang, Aaron C-H Chen, Michael R. Hamblin
Author Bio(s)
Editorial Reviews
"… a great resource for scientists and graduate students in biomedical engineering and optics. In addition to providing background information on classical optics, irradiation guidelines and tissue optical properties, this book offers a thorough treatment of tomographic and microscopic imaging technologies."
—Optics & Photonics News, January 2013
"This handbook is a successful attempt to provide as much as possible information to a number of physicists, R&D engineers, clinicians and scientists who would like to apply contemporary concepts and techniques to solving biomedical diagnostic and therapeutic challenges. It often covers areas that are not conventionally addressed, and is generally thought-provoking and brain-stimulating … . The book can serve as an excellent tutorial for students and young investigators finding their way through the intense and exciting field of biomedical optics. It is a relevant reference for scientists and also a good teaching tool. … a good balance between introductory knowledge and high-level expertise, without burdening the reader with excessive data. What makes it really unique is its scope. This is a handbook of thirty-five chapters, covering an enormous breadth of material… . An additional value is that the book is truly state of the art."
—Boris Gramatikov, Johns Hopkins University School of Medicine, Biomedical Engineering Online, February 2012
"Handbook of Biomedical Optics is a useful addition as an overall source to help educate the new and present generation of graduate students, researchers, and medical professionals. … highly recommend it. It provides an in-depth review and overall treatment covering most areas of biomedicine from the ground-level foundations of optics to background on photon transport in tissues, theory, and experiments. … Handbook of Biomedical Optics is a major contribution to the biomedical optics field and will serve as a great resource."
—Journal of Biomedical Optics, December 2011
