Heart Failure, Second Edition

Heart Failure, Second Edition

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Summary

Heart Failure, Second Edition has been updated to provide the latest advancements in heart failure research. Supplemented by more than 200 high-quality figures and illustrations, the book helps cardiologists and emergency care physicians quickly and accurately identify the cause and severity of a patient’s cardiac impairment.

New topics in this edition include:

  • Developments in mechanical and pharmacologic treatments
  • Discoveries in developmental biology
  • Up-and-coming imaging modalities
  • Surgical options for mechanical circulatory support and cardiac transplantation
  • Pharmacogenomics and gene-based and cell-based therapies
  • Gene expression/recurrence in heart failure
  • Changes in metabolic substrate utilization and pathways

Table of Contents

Part 1: Cellular and Molecular Basis for Heart Failure
A Brief Primer on the Development of the Heart
Serge Gregoire and Sean Wu
The Genetics of Dilated and Hypertrophic Cardiomyopathies
Calum Macrae
Molecular Signaling Networks Underlying Cardiac Hypertrophy and Failure
Gerald W Dorn II MD
Excitation-Contraction Coupling in the Normal and Failing Heart
Mattew Coggins, Bernhard Haring, Federica del Monte
Myocardial energetics and cellular metabolism in the failing heart
Joanne S. Ingwall
Animal Models of Heart Failure
William Carlson

Part II: Pathophysiology of Heart Failure
Ventricular Remodeling and Secondary Valvular Dysfunction in Heart Failure Progression
Kibar Yared, Judy Hung
Neurohormonal and Cytokine Activation in Heart Failure
Dennis McNamara
Cardiomyopathies in the Adult
Richard Rodeheffer
Water and Salt: the cardiorenal syndrome
Maria Rosa Costanzo

Part III: The Demographics, Diagnosis and Monitoring of Heart Failure:
The Clinical Syndrome of Heart Failure
Thomas DiSalvo, Jordon Shin
Clinical Profiles and Bedside Assessment
Lynne Warner Stevenson
Prognosis in Heart Failure
J. Susie Woo, Wayne C. Levy,
Biomarkers in Heart Failure
Ravi V. Shah, MD and Thomas J. Wang
Noninvasive Imaging Modalities for the Evaluation of Heart Failure
Kimberly A. Parks and Malissa J. Wood
Role of Invasive Monitoring in Heart Failure: Pulmonary Artery Catheters in the Post-ESCAPE Era
W. H. Wilson Tang, Gary S. Francis

Part IV: The Medical Treatment of Clinical Heart Failure
Conventional Therapy of Chronic Heart Failure: Diuretics, Vasodilators, and Digoxin
G. William Dec, MD
Conventional Therapy of Chronic Heart Failure: Beta-Adrenergic Blockers
G. William Dec
Angiotensin Receptor Blockers for Heart Failure
George V. Moukarbel
Anticoagulation in Systolic Heart Failure
Ronald Freudenberger
Role of Mineralocorticoid Antagonists in Patients with Heart Failure
Mara Giattina, Flora Sam
Treatment of Heart Failure with Preserved Ejection Fraction
Barry A. Borlaug
Cardiac Resynchronization Therapy
William T. Abraham, MD
Management of Atrial and Ventricular Arrhythmias in Heart Failure
Usha Tedrow, William G. Stevenson
Ultrafiltration for the management of volume overload
Bradley A. Bart
Heart Failure and Palliative Care
Joshua Hauser, Robert Bonow

Part V: Molecular and Biologic Therapies
Gene Therapy for Heart Failure
Stefan Janssens

Editor Bio(s)

      Marc Semigran is Associate Professor of Medicine, Harvard Medical School; Director, Heart Failure and Transplant Service, Massachusetts General Hospital; Attending Physician, Cardiac Catheterization, Laboratory, Medical Services, Coronary Care Unit, and Cardiology Consultation Service, Massachusetts General Hospital, Boston, Massachusetts, USA. He is a member of fellow of several organizations, including the American College of Physicians, the American College of Cardiology, the American Heart Association, the International Society of Heart and Lung Transplantation, and the Working Group of Transplant Cardiologists.

      Dr. Semigran is a reviewer for several publications, including the American Journal of Cardiology, Anesthesia, Journal of the American College of Cardiology, New England Journal of Medicine, Journal of the American College of Cardiology, Arthritis and Rheumatism, Circulation, and the Journal of Heart and Lung Transplantation. He also contributed to the first edition of Heart Failure.

      Jordan T. Shin is Professor of Medicine, Harvard Medical School and Assistant Physician, Massachusetts General Hospital, Boston, Massachusetts, USA. He is a member of numerous organizations, including the Massachusetts Medical Society, the American Medical Association, American College of Cardiology, the American Association for the Advancement of Science, Member, the American Heart Association, and the Heart Failure Society of America.

Editorial Reviews

" … a book for clinicians and scientists who not only seek recommendations on heart failure treatment but also look for deeper insights into the molecular mechanisms and the pathophysiology of this challenging syndrome."
European Heart Journal

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