Reproductive Toxicology, Third Edition

Reproductive Toxicology, Third Edition

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ISBN 9781420073430
Cat# 73435



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  • Covers new and critical mechanistic topics such as epigenetics and omics
  • Presents one of the first significant compilations of epigenetic mechanisms
  • Provides an in-depth analysis of the role of genomics, proteomics, and metabolomicsin human reproduction
  • Considers new guidelines with respect to the latest research applications in the field


Thoroughly examining the popular and expanding field of reproductive toxicology, this newly revised and expanded third edition provides the latest, cutting-edge scientific developments in this constantly evolving discipline. Reproductive Toxicology’s contributors are experienced regulatory agency and Clinical Research Organization representatives who currently utilize the new techniques discussed in the text and continue to revolutionize reproductive toxicology research.

This ground-breaking resource includes:

  • New and important critical mechanistic topics such as epigenetics and omics
  • The first significant compilation of epigenetic mechanisms
  • An in-depth analysis of the role of genomics, proteomics, and metabolomicsin human reproduction
  • New guidelines with respect to the latest research applications in the field

Table of Contents

Normal reproduction and development
Biology and physiology of fertilization, John Parrish
Normal development of the male reproductive system, Reza J. Rasoulpour, M. Sue Marty, Kamin J. Johnson, and Edward W. Carney
Normal development of the female reproductive system, Jerome M. Goldman and Ralph L. Cooper
Development of the mammalian nervous system, Kimberly Ehman

Regulatory evaluation of reproduction
FDA and ICH perspectives on reproductive and developmental toxicology, Rochelle W. Tyl
EPA and OECD perspectives on reproductive and developmental toxicity testing, Susan L. Makris
Reproductive study evolution and IND submissions for the Food and Drug Administration, Robert W. Kapp, Jr.

Developmental toxicity of systemic organ systems
Developmental immunotoxicology, Mark Collinge, Leigh Ann Burns-Naas, and Thomas T. Kawabata
Developmental neurotoxicology, Merle G. Paule and William Slikker, Jr.
Developmental toxicology of the respiratory system, Raymond G. York and Robert M. Parker
Developmental toxicity of the kidney, Gregg D. Cappon and Mark E. Hurtt
Developmental toxicology of the liver, Kartik Shankar and Harihara M. Mehendale
Cardiovascular development and malformation, John M. DeSesso and Arthi G. Venkat

Toxicity of the reproductive process
Male reproductive toxicity, Robert W. Kapp, Jr.
Female reproductive toxicity, Ralph L. Cooper and Jerome M. Goldman
Toxicity of the pregnant female reproductive system, Mallikarjuna Basavarajappa, Jackye Peretz, Tessie Paulose, Rupesh Gupta, Ayelet Ziv-Gal, and Jodi A. Flaws
Epigenetic reproductive toxicants, Retha Newbold and Harriet Karimi Kinyamu
Cumulative effects of in utero administration to mixtures of reproductive toxicants in the male rat: a systems biology framework, L. Earl Gray, Jr., Cynthia V. Rider, Vickie S. Wilson, Kembra L. Howdeshell, Andrew K. Hotchkiss, Chad Blystone, Johnathan R. Furr, Christy R. Lambright, and Paul Foster
Metals and metal compounds in reproductive and developmental toxicology, Mari S. Golub
Omics in reproductive and developmental toxicology, Susan Sumner, Rodney Snyder, Jason Burgess, Timothy Fennell, and Rochelle W. Tyl

Editorial Reviews

"Due to the wealth of new information that we have gained over the last 15 years, a new edition is absolutely necessary to keep pace with the study of environmental substances and their effects on reproduction and development ... This book easily leads the pack in the field of research toxicology. For those interested in keeping current in this field, it is a must-have. It is important to note that this book should be on the shelf of any physician-scientist studying the impact of environmental exposures on human health, reproduction, and development."
Doody's Review Service

"This new edition of the Target Organ Toxicology series is a welcome addition to the series and, as with the previous two editions, it has brought together the leading authorities in the field to provide an authoritative text on the increasingly important topic of reproductive toxicology. The breadth of the topics covered is truly impressive and while there is continuity with the previous two editions, this third edition covers areas which will undoubtedly be a surprise to some, as it was to this reviewer."
The British Toxicology Society Newsletter