Advanced Search Search Textbooks Only

Autism: Oxidative Stress, Inflammation, and Immune Abnormalities
Abha Chauhan, Inst. Basic Research Developmental Disabilities, Staten Is.,; Ved Chauhan, Inst. Basic Research Developmental Disabilities, Staten Is.,; Ted Brown, Inst. Basic Research Developmental Disabilities, Staten Is.,
Price:  $159.95
Cat. #:  68814
ISBN:  9781420068818
ISBN 10:  1420068814
Publication Date:  October 26, 2009
Number of Pages:  452

Binding(s):  Hardback

Email this title to a friend
Related Titles
Neurobehavioral Genetics: Methods and Applications, Second Edition
Editor(s):  Byron C. Jones, Pennsylvania State University, University Park, USA;  Pierre Mormede, INRA, Head-Laboratoire de Neurogenetique et Stress, Bordeaux, France
Publication Date: August 30, 2006
Price: $149.95
Understanding Autism: From Basic Neuroscience to Treatment
Editor(s):  Steven O. Moldin, University of Southern California, Washington, DC, USA;  John L R Rubenstein, University of California, San Francisco, USA
Publication Date: April 25, 2006
Price: $175.95
Methods in Genomic Neuroscience
Editor(s):  Hemin R. Chin, National Eye Institute/NIH, Bethesda, Maryland, USA;  Steven O. Moldin, University of Southern California, Washington, DC, USA
Publication Date: September 26, 2001
Price: $149.95
Description
Table of Contents
Reviews
Downloads & Updates
Features
  • Covers the relationship between oxidative stress and autism

  • Discusses new research on immunological abnormalities and inflammation

  • Provides information on research results with animal models

  • Reviews the most current information on genetic and environmental interactions in autism

  • Looks at hopeful avenues for novel therapeutic interventions


Summary

In 2007, the Centers for Disease Control and Prevention issued an autism alarm, estimating that one in 150 children may be affected by autism spectrum disorder. Autism has been treated mainly with technical approaches: principally applied behavior analysis and psychopharmacology. The findings in this book implicate oxidative stress as a common feature in autism, and support the claim that oxidative stress and intracellular redox imbalance can be induced or triggered in autism by exposure to certain environmental agents. Such findings could point the way to new treatment approaches in autism.

Autism: Oxidative Stress, Inflammation, and Immune Abnormalities brings together a wealth of cutting-edge evidence that is already influencing how we treat this serious condition. It looks at the role of neuropathological abnormalities, genetics, and those factors common to oxidative stress such as inflammation, immune dysfunction, aberrant cellular signaling, and gene-environment interactions. Among dozens of research topics, this volume —

  • Looks at interactions between genetic and environmental factors such as the maternal immune environment and prenatal/postnatal environmental stressors
  • Summarizes evidence for oxidative damage and inflammation in autism
  • Introduces a PDD behavior inventory as a tool for assessing autism
  • Considers autism as an aberrant adaptive response to neuroinflammation and oxidative stress
  • Examines the role of abnormal calcium signaling and the hypothesis that it may represent a target for novel therapeutics
  • Presents a hypothesis that autism arises from the dysregulation of a unified gut/brain system rather than originating in the brain alone
  • Proposes the utility of using a biopsychosocial method to treat autism

This book shows us that autism is not only developmental but also a chronic condition based on active pathophysiology, and that it is not only behavioral but also presents somatic and systemic features. The findings in these chapters support the theory that oxidative stress plays an important role in autism. They also point to the value of conducting in-depth mechanistic studies as a way to uncover new targets for therapeutic intervention in autism.