Cancer Epigenetics

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Features

  • Describes the importance of dietary and environmental factors on cancer epigenetics
  • Highlights diagnostic and prognostic aspects of epigenetics in cancer and advances in gene therapy
  • Covers emerging aspects, such as RNA epigenetics, chromosomal position effects, and epigenomics
  • Addresses the role of polycomb-group genes in cancer
  • Summary

    During the past few decades, it has become increasingly apparent that heredity is not the sole determining factor in disease development, such as cancer. This landmark work covers a wide array of aspects in the relatively new area of epigenetics, ranging from its role in the basic mechanisms of tumorigenesis, to the newest epigenetic drugs being developed and used for cancer therapy.

    Cancer Epigenetics presents in-depth discussions of DNA methylation alterations, histone and RNA modifications, and nucleosome remodeling, which are all intimately involved in the formation of tumors. It also analyzes metabolic influences on cancer epigenetics and advances in epigenetic cancer gene therapy.

    Discusses the Latest Advances in the Role of Epigenetics in Tumor Initiation, Progression, and Metastasis

    With stand-alone chapters written by research pioneers in the field, this definitive resource covers—

  • DNA methylation and cancer
  • Histone modifications in cancer
  • Emerging areas of cancer epigenetics
  • Epigenetics in the diagnosis, prognosis, and therapy of cancer
  • Future directions in epigenetic cancer research
  • Bringing together different topics into a single compilation, this text is a prime resource for those with interests ranging from the basic mechanisms of tumor biology to cancer therapy. It also serves as a core textbook for advanced courses with a focus on genetic diseases, molecular biology, and/or cancer. This seminal work answers the call for a thorough and authoritative reference that covers the critical and contemporary aspects of this revolutionary field.

    Table of Contents

    The Role of Epigenetics in Cancer, T.O. Tollefsbol
    Section 1:  DNA Methylation and Cancer
    DNA Hypomethylation in Cancer, P.L. Molloy
    DNA Hypermethylation in Oncogenesis, J.T. DeAngelis, J.B. Berletch, L.G. Andrews, and T.O. Tollefsbol
    Imprinting Alterations in Tumorigenesis, J. Bernier-Latmani and P. Shaw
    Proteins that Modulate DNA Methylation Aberrations in Cancer, S. L. Walthall, S.M.O. Phipps, L.G. Andrews, and T. O. Tollefsbol
    The Role of DNA Methylation in Cancer Progression, S.-W. Choi and S. Friso
    Section 2:  Histone Modifications in Cancer
    Alterations in Histone Acetylation in Tumorigenesis, S.N. Saldanha and T.O. Tollefsbol
    Histone Methylation and the Initiation of Cancer, S. Huang
    The Role of Sirtuins in Aging and Tumorigenesis, X. Zhang, T. I. Hseih, S. V. Nicosia, and W. Bai
    Proteins that Alter Histone Modifications in Cancer, A. Ao and J. Lu
    Dietary and Environmental Influences on Histone Modifications in Cancer, S.N. Saldanha, V. Nandakumar, A. Elgavish, and T. O. Tollefsbol
    Section 3:  Other Epigenetic Aspects of Cancer
    Noncoding RNAs in Cancer, M. Szymanski and J. Barciszewski
    Cancer-linked DNA Hyper- and Hypomethylation: Chromosome Positional Effects, M. Ehrlich
    Chromatin Remodeling and Cancer, S. Pennings and R.R. Meehan
    Poly-ADP-ribosylation in Cancer, R.N. Sharan
    Polycomb Group Proteins in Tumorigenesis, H.E.C. Niessen and J.W. Voncken
    Cancer and Aging: The Epigenetic Connection, C.A. Cooney
    Section 4:  Epigenetics in the Diagnosis, Prognosis and Therapy of Cancer
    DNA Methylation in Tumor Diagnosis, K. Ramachandran, E. Gordian and R. Singal
    DNA Methylation Profiles as Prognostic Markers for Cancer, S. Thiagalingam and P. Papageorgis
    Diagnosing Cancer Using Histone Modification Analysis, M. Verma and D. Kumar
    Histone Modifications in Cancer Biology and Prognosis, M.A. McBrian, D. B. Seligson, and S. K. Kurdistani
    Histone Deacetylase Inhibitors in Cancer Therapy, A.M. Sargeant, S.K. Kulp, Y.-S. Lu, A.-L. Cheng, and C.-S. Chen
    Methylation Changes in Neoplasia: Diagnostic and Therapeutic Implications, E. Hatzimichael, J. Stebbing, and T. Crook
    Clinical Trials and Approved Drugs for Epigenetic Cancer Therapy, D.M.E.I. Hellebrekers and M. van Engeland
    Section 5:  Future Directions
    Future Directions in Epigenetic Cancer Research , J. Peedicayil

    Editorial Reviews

    "This book is an indispensable reference for those with interests from the basic mechanisms of tumor biology to cancer therapy. Serving as a core textbook for advanced courses with a focus on genetic diseases, molecular biology, and/or cancer, this seminal work answers the call for a thorough and authoritative reference that covers the critical and contemporary aspects of this revolutionary field."

    – In Anticancer Research, 2009, Vol. 29