Cancer Epigenetics

Trygve Tollefsbol

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September 19, 2008 by CRC Press
Reference - 472 Pages - 7 Color & 18 B/W Illustrations
ISBN 9781420045796 - CAT# 45792

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Features

  • Describes the importance of dietary and environmental factors on cancer epigenetics
  • Highlights diagnostic and prognostic aspects of epigenetics in cancer and advances in gene therapy
  • Covers emerging aspects, such as RNA epigenetics, chromosomal position effects, and epigenomics
  • Addresses the role of polycomb-group genes in cancer
  • Summary

    During the past few decades, it has become increasingly apparent that heredity is not the sole determining factor in disease development, such as cancer. This landmark work covers a wide array of aspects in the relatively new area of epigenetics, ranging from its role in the basic mechanisms of tumorigenesis, to the newest epigenetic drugs being developed and used for cancer therapy.

    Cancer Epigenetics presents in-depth discussions of DNA methylation alterations, histone and RNA modifications, and nucleosome remodeling, which are all intimately involved in the formation of tumors. It also analyzes metabolic influences on cancer epigenetics and advances in epigenetic cancer gene therapy.

    Discusses the Latest Advances in the Role of Epigenetics in Tumor Initiation, Progression, and Metastasis

    With stand-alone chapters written by research pioneers in the field, this definitive resource covers—

  • DNA methylation and cancer
  • Histone modifications in cancer
  • Emerging areas of cancer epigenetics
  • Epigenetics in the diagnosis, prognosis, and therapy of cancer
  • Future directions in epigenetic cancer research
  • Bringing together different topics into a single compilation, this text is a prime resource for those with interests ranging from the basic mechanisms of tumor biology to cancer therapy. It also serves as a core textbook for advanced courses with a focus on genetic diseases, molecular biology, and/or cancer. This seminal work answers the call for a thorough and authoritative reference that covers the critical and contemporary aspects of this revolutionary field.