Regulation of Gene Expression by Small RNAs
Features
- Presents a cutting edge introduction to, and comprehensive overview of microRNAs
- Describes the basic biology of microRNAs, as well as their role in disease
- Features contributions from leading experts in the field
- Provides researchers with the findings, methods, and tools needed for continuing research
- Points the way to novel treatments for challenging diseases
Summary
New Findings Revolutionize Concepts of Gene Function
Endogenous small RNAs have been found in various organisms, including humans, mice, flies, worms, fungi, and bacteria. Furthermore, it’s been shown that microRNAs acting as cellular rheostats have the ability to modulate gene expression. In higher eukaryotes, microRNAs may regulate as much as 50 percent of gene expression.
Regulation of Gene Expression by Small RNAs brings together the pioneering work of researchers who discuss their work involving a wide variety of small RNA regulatory pathways in organisms ranging from bacteria to humans. In addition to exploring the biogenesis and processing of these regulatory RNAs, they also consider the functional importance of these pathways in host organisms. Assisting current and future researchers, this unique groundbreaking work —
- Provides a suite of cutting-edge resources for the study of microRNA ontology and function
- Includes a technology guide for those seeking to assay microRNA expression
- Explores the mechanisms by which microRNAs regulate gene expression in animal cells, including the regulation of gene expression by RNA-mediated transcriptional gene silencing
- Discusses a fast and low-cost approach for reversing genetic influences in mammals
- Looks at breakthroughs in the use of microRNA-based therapy for HIV and cancer
This volume captures the essence of the breadth and excitement surrounding the newly discovered regulatory roles of small RNAs. The powerful new approach in the study of gene function described in this text is leading to some remarkable findings that have the potential to revolutionize our understanding of genetic function and the treatment of diseases otherwise considered intractable.
Table of Contents
MicroMining:
Computational Approaches to microRNA Discovery, A. Grundhoff
Regulation of
Translation and mRNA Stability by Hfq-Binding Small RNAs in Escherichia
coli, H. Aiba
Mechanisms by
which microRNAs Regulate Gene Expression in Animal Cells, Y. Yu and T. W.
Nilsen
The microRNAs of
Caenorhabditis elegans, M. J. Nolde and F. J. Slack
Biogenesis and
Function of Plant microRNAs, Z. Havelda
Methods to
Quantify microRNA Gene Expression, L. A. Neely
Regulation of
Alternative Splicing by microRNAs, R. K. Gaur
Recent Progress
in Polymerase II-Mediated Intronic microRNA Expression Systems, S.-L. Lin
and S.-Y. Ying
MicroRNA-Based
RNA Polymerase II Expression Vectors for RNA Interference in Mammalian Cells,
A. B. Vojtek, K.-H. Chung, P. D. Patel, and D. L. Turner
Transgenic RNAi:
A Fast and Low-Cost Approach to Reverse Genetics in Mammals, L. Qiu and Z.
Xu
Symphony of
AIDS: A microRNA-Based Therapy, Y. R. Fujii
MicroRNAs and
Cancer: Connecting the Dots, S. D. Jayasena
Mammalian
Transcriptional Gene Silencing by Small RNAs, D. H. Kim and J. J. Rossi
Regulation of
Gene Expression by RNA-Mediated Transcriptional Gene Silencing, K. V. Morris
