Digital Microfluidic Biochips

Digital Microfluidic Biochips: Synthesis, Testing, and Reconfiguration Techniques

Published:
Content:
Author(s):
Free Standard Shipping

Purchasing Options

Hardback
ISBN 9780849390098
Cat# 9009

$184.95

$147.96

SAVE 20%


eBook (VitalSource)
ISBN 9781420008302
Cat# E9009

$184.95

$129.47

SAVE 30%


eBook Rentals

Other eBook Options:
 

Features

  • Presents a system-level design and optimization strategy specifically designed for digital microfluidic biochips
  • Applies classical VLSI synthesis techniques to digital microfluidics-based biochips
  • Integrates operation scheduling, resource binding, droplet routing, and module placement in one synthesis procedure
  • Proposes cost-effective test methodologies that include test planning, defect-oriented testing, and diagnosis
  • Analyzes two defect tolerance schemes based on space redundancy and graceful degradation, respectively
  • Evaluates design automation tools using a set of real life bioassays
  • Summary

    Digital Microfluidic Biochips focuses on the automated design and production of microfluidic-based biochips for large-scale bioassays and safety-critical applications. Bridging areas of electronic design automation with microfluidic biochip research, the authors present a system-level design automation framework that addresses key issues in the design, analysis, and testing of digital microfluidic biochips.

    The book describes a new generation of microfluidic biochips with more complex designs that offer dynamic reconfigurability, system scalability, system integration, and defect tolerance. Part I describes a unified design methodology that targets design optimization under resource constraints. Part II investigates cost-effective testing techniques for digital microfluidic biochips that include test resource optimization and fault detection while running normal bioassays. Part III focuses on different reconfiguration-based defect tolerance techniques designed to increase the yield and dependability of digital microfluidic biochips.

    Expanding upon results from ongoing research on CAD for biochips at Duke University, this book presents new design methodologies that address some of the limitations in current full-custom design techniques. Digital Microfluidic Biochips is an essential resource for achieving the integration of microfluidic components in the next generation of system-on-chip and system-in-package designs.

    Table of Contents

    PART I
    SYNTHESIS TECHNIQUES
    Introduction
    Technology Issues
    Digital Microfluidic Biochips
    Microfluidic Biochip Design Challenges
    Book Outline
    Architectural-Level Synthesis
    Background
    High-Level Synthesis Methodology
    Simulation Experiments
    Module Placement
    Background
    Module Placement Problem
    Fault Tolerance for Digital Microfluidic Biochips
    Experimental Evaluation
    Unified Synthesis Methodology
    Problem Formulation
    PRSA-Based Algorithm
    Enhancement for Defect Tolerance
    Experimental Evaluation
    Droplet Routing
    Background
    Problem Formulation
    Routing Method
    Experimental Evaluation
    PART II
    TESTING TECHNIQUES
    Test Methodology
    Background
    Classification of Faults
    Unified Detection Mechanism
    Parametric Fault Testing
    Simulation Experimental Setup
    Test Planning
    Problem Definition
    Analysis of Computational Complexity
    Integer Linear Programming Model for OPP
    Heuristic Algorithms
    Simulation Results
    Concurrent Testing
    Concurrent Testing Methodology
    Optimal Scheduling for Concurrent Testing
    Concurrent Testing Example
    Defect-Oriented Testing and Diagnosis
    Fault Modeling
    Defect-Oriented Experiment
    Testing and Diagnosis
    Real-Life Application
    PART III
    RECONFIGURATION TECHNIQUES
    Reconfiguration Schemes
    Proposed Reconfiguration Schemes
    Example Evaluation
    Defect Tolerance Based on Space Redundancy
    Background
    Microfluidic Array with Hexagonal Electrodes
    Defect-Tolerant Designs
    Estimation of Yield Enhancement
    Evaluation Example
    Defect Tolerance Based on Graceful Degradation
    Tile-Based Architecture
    Clustered Defect Model
    Graceful Degradation with Reconfiguration
    Simulation Results
    Conclusions and Future Work
    Contributions of the Book
    Future Work
    Bibliography
    Index