Medicinal Protein Engineering

Medicinal Protein Engineering

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ISBN 9780849373688
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Features

  • Presents an overview of experimental approaches to protein construction
  • Discusses the most current information on computational approaches to protein design
  • Reviews available web computational resources, machine learning, and phylogenetic techniques
  • Includes several full-color illustrations to further understanding of complex concepts

 

Summary

An All-Inclusive Review of the Achievements and Trends in the Fast-Growing Protein Engineering Field

From humble beginnings like making fire for mere survival, engineering now steadfastly penetrates all aspects of our lives and even life itself at the molecular level. Protein engineering is a molecular biological discipline focused on designing and constructing novel proteins with desired properties. The currently limited understanding of the relationship between protein structure and function greatly hinders rational protein design. However, despite great challenges, protein engineering has become a major molecular discipline with a large array of successful applications to many complex medicinal problems.

Medicinal Protein Engineering sheds light on this largely unchartered field, covering major strategies for engineering of proteins with predetermined biological properties. It discusses computational approaches to protein design and experimental approaches to protein construction. This volume also explores the tight connection between protein and genetic engineering. It moves researchers beyond experimental protein construction and theoretical protein design to the medicinal applications of engineered proteins.

Examines Medicinal Applications of Protein Engineering for the Diagnosis, Treatment, and Prevention of Diseases

Focusing on the application of protein engineering to medicine, this seminal work outlines the appropriate techniques for studying protein properties and building mathematical engineering models of novel vaccines, diagnostic reagents, and therapeutic treatments. As a truly comprehensive assessment of the medical protein engineering research available and its future implications for disease control and prevention, this is an indispensable reference for biological researchers in this groundbreaking field.

Table of Contents

Computational Approaches

Web Resources for Protein Analysis, S. A. Cammer and M. Czar

Artificial Neural Networks for Therapeutic Protein Engineering, J. Lara

Phylogenetics and Medicinal Protein Engineering, M.A. Purdy

Clustering and Classification Approaches to Identifying Protein Properties, L.M. Ganova-Raeva and Z.E. Dimitrova

Analysis of Coordinated Substitutions in Proteins, D. Campo

Protein Engineering Targets: Vaccine Tuning the Immune Response to Our Advantage: Design of Vaccines with Tailored Functions, M.F. Bachmann and T.A. Röhn

Modification of HIV-1 Envelope Glycoprotein to Enhance Immunogenicity, M. Aidoo, S. Butera, and D. Ellenberger

Engineering Better Influenza Vaccines: Traditional and New Approaches, P.M. Pushko, R.A. Bright, T.M. Tumpey, and G.E. Smith

Construction of Novel Vaccines on the Basis of Virus-Like Particles: Hepatitis B Virus Proteins as Vaccine Carriers, P. Pumpens, R.G. Ulrich, K. Sasnauskas, A. Kazaks, V. Ose, and E. Grens

Polyomavirus-Derived Virus-Like Particles, R.G. Ulrich, A. Gedvilaite, T. Voronkova, A. Kazaks, R. Johne, and K. Sasnauskas

Papillomavirus-Derived Virus-Like Particles, A. Kazaks and T. Voronkova

Recombinant Vaccines Against Hepatitis Viruses, J. Yokosawa, N.O. Perez, and L.M.G. Rossi

Protein Engineering Targets: Diagnostics and Therapy Designer Diagnostic Reagents and Allergens, A. Obriadina

Peptide-Based Diagnostic Assays, M.J. Gómara and I. Haro

Recombinant Antibodies, A. Likhacheva and T. Ulanova

Protein Engineering for HIV Therapeutics, J.M. Smith, D. Ellenberger, and S. Butera

Recombinant Enzymes with New and Improved Properties, L.M. Ganova-Raeva

Special Expression Systems

Production of Pharmaceutical Compounds in Plants, M.A. Gómez Lim

Plant Virus Biotechnology Platforms for Expression of Medicinal Proteins, A. Zeltins

Alphaviruses: Multiplicity of Vectors and Their Promising Application as Vaccines and Cancer Therapy Agents, A. Zajakina, B. Niedre-Otomere, J. Alekseeva, and T. Kozlovska

Index