Medicinal Protein Engineering

Yury E. Khudyakov

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December 1, 2008 by CRC Press
Reference - 584 Pages - 63 B/W Illustrations
ISBN 9780849373688 - CAT# 7368

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Features

  • Presents an overview of experimental approaches to protein construction
  • Discusses the most current information on computational approaches to protein design
  • Reviews available web computational resources, machine learning, and phylogenetic techniques
  • Includes several full-color illustrations to further understanding of complex concepts

 

Summary

An All-Inclusive Review of the Achievements and Trends in the Fast-Growing Protein Engineering Field

From humble beginnings like making fire for mere survival, engineering now steadfastly penetrates all aspects of our lives and even life itself at the molecular level. Protein engineering is a molecular biological discipline focused on designing and constructing novel proteins with desired properties. The currently limited understanding of the relationship between protein structure and function greatly hinders rational protein design. However, despite great challenges, protein engineering has become a major molecular discipline with a large array of successful applications to many complex medicinal problems.

Medicinal Protein Engineering sheds light on this largely unchartered field, covering major strategies for engineering of proteins with predetermined biological properties. It discusses computational approaches to protein design and experimental approaches to protein construction. This volume also explores the tight connection between protein and genetic engineering. It moves researchers beyond experimental protein construction and theoretical protein design to the medicinal applications of engineered proteins.

Examines Medicinal Applications of Protein Engineering for the Diagnosis, Treatment, and Prevention of Diseases

Focusing on the application of protein engineering to medicine, this seminal work outlines the appropriate techniques for studying protein properties and building mathematical engineering models of novel vaccines, diagnostic reagents, and therapeutic treatments. As a truly comprehensive assessment of the medical protein engineering research available and its future implications for disease control and prevention, this is an indispensable reference for biological researchers in this groundbreaking field.