Human Developmental Toxicants: Aspects of Toxicology and Chemistry

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ISBN 9780849372292
Cat# 7229

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ISBN 9781420006759
Cat# E7229

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Features

  • Discusses 50 known agents that adversely effect human development as a result of exposure
  • Offers insight into identifying the chemical properties responsible for adverse effects on human development
  • Focuses on the relationship between chemical characteristics and toxicological properties of important toxicants
  • Contains pertinent animal data to compare and correlate with human data
  • Supplies an accompanying CD-ROM with three-dimensional chemical structures, chemical properties and toxicological data in SD and Excel file form for each toxicant
  • Summary

    Presenting the first database of its kind, this unique reference illustrates the relationships between the chemistry and developmental toxicity of a number of important pharmaceuticals and industrial toxicants. Human Developmental Toxicants contains up-to-date and concise information on the chemical structures, properties, and biological activities for 50 known agents that adversely affect prenatal and postnatal human development in terms of growth, viability, structure, and function.

    This book presents data linking chemical and structural properties of specific toxicants as they relate to toxic effects, dosage, timing, and route of exposure. Focusing on one compound per chapter, the book also includes associated biological data from animals for each agent covered. An accompanying CD summarizes all of the data discussed in the text within an electronic database. In addition, the CD contains three-dimensional structure representations and 49 calculated physicochemical and topological parameters of the selected molecules. This information is useful for building structure activity relationship (SAR) models linking the chemical properties with observed human developmental toxicity.

    As scientists continue to explore how chemicals alter human development, Human Developmental Toxicants contains the necessary information to further identify which chemical properties are responsible for adverse effects. This reference provides toxicologists, teratologists, chemists and other scientists with the latest data and information needed to perform risk assessments, predict chemicals that may produce developmental toxicity, and regulate harmful exposure.

    Table of Contents

    Each chapter is dedicated to a single compound and provides a general introduction followed by a description of that compound's developmental toxicology in animals and humans, a detailed analysis of its chemistry and calculated physicochemical properties, and references.

    Aminopterin
    Busulfan
    Cyclophosphamide
    Methotrexate
    Chlorambucil
    Mechlorethamine
    Cytarabine
    Tretinoin
    Propranolol
    Penicillamine
    Vitamin A
    Carbamazepine
    Danazol
    Paramethadione
    Carbon Monoxide
    Formaldehyde
    Isotretinoin
    Captopril
    Misoprostol
    Streptomycin
    Methimazole
    Ethylene Oxide
    Tetracycline
    Caffeine
    Thalidomide
    Primidone
    Fluconazole
    Ergotamine
    Propylthiouracil
    Medroxyprogesterone
    Cocaine
    Quinine
    Methylene Blue
    Warfarin
    Phenobarbital
    Trimethoprim
    Methyltestosterone
    Disulfiram
    Valproic Acid
    Carbon Disulfide
    Norethindrone
    Phenytoin
    Etretinate
    Toluene
    Ethisterone
    Acitretin
    Valsartan
    Diethylstilbestrol
    Pseudoephedrine
    Ethanol
    Discussion and Summary
    Appendix I: Physicochemical Parameter Histograms
    Appendix II: Topological Parameter Histograms
    Appendix III: Description of of Accompanying CD
    Index

    Downloads / Updates

    Resource OS Platform Updated Description Instructions
    7229_CD_Files.zip Cross Platform March 06, 2014