Biocatalysis in the Pharmaceutical and Biotechnology Industries
Features
Summary
Because enzyme-catalyzed reactions exhibit higher enantioselectivity, regioselectivity, substrate specificity, and stability, they require mild conditions to react while prompting higher reaction efficiency and product yields. Biocatalysis in the Pharmaceutical and Biotechnology Industries examines the use of catalysts to produce fine chemicals and chiral intermediates in a variety of pharmaceutical, agrochemical, and other biotechnological applications.
Written by internationally recognized scientists in biocatalysis, the authors analyze the synthesis of chiral intermediates for over 60 brand-name pharmaceuticals for a wide range of drug therapies and treatments. From starting material to product, the chapters offer detailed mechanisms that show chiral intermediates and other by-products for each reaction—including hydrolytic, acylation, halogenation, esterification, dehalogenation, oxidation-reduction, oxygenation, hydroxylation, deamination, transamination, and C–C, C–N, C–O bonds formation. Cutting-edge topics include advanced methodologies for gene shuffling and directed evolution of biocatalysts; the custom engineering of enzymes; the use of microbial cells and isolated biocatalysts; the use of renewable starting materials; and generating novel molecules by combinatorial biocatalysis and high-throughput screening.
Focusing on industrial applications, the book also considers factors such as bulk processes, instrumentation, solvent selection, and techniques for catalyst immobilization, reusability, and yield optimization throughout. Biocatalysis in the Pharmaceutical and Biotechnology Industries showcases the practical advantages and methodologies for using biocatalysts to develop and produce chiral pharmaceuticals and fine chemicals.
Table of Contents
Nitrilases and Nitrile Hydratases; R. DiCosimo
Biocatalytic Deracemization: Dynamic Resolution, Stereoinversion, Enantioconvergent Processes and Cyclic Deracemization; Y.Simeó, W. Kroutil, and K. Faber
A Decade of Biocatalysis at Glaxo Wellcome; M. Mahmoudian
Biocatalysis for Synthesis of Chiral Pharmaceutical Intermediates; R.N. Patel
Directed Evolution of Lipases and Esterases for Organic Synthesis; A. Hidalgo and U.T. Bornscheuer
Flavin-Containing Oxidative Biocatalysts; M.W. Fraaije and W.J.H. van Berkel
Preparation of Chiral Pharmaceuticals through Enzymatic Acylation of Alcohols Amines; V. Gotor-Fernández, F. Rebollledo, and V. Gotor
Dynamic Kinetic Resolution and Asymmetric Transformations by Enzyme–Metal Combinations; M.J. Kim, Y. Ahn, and J. Park
Biotransformation of Natural or Synthetic Compounds for the Generation of Molecular Diversity; R. Azerad
Applications of Aromatic Hydrocarbon Dioxygenases; R.E. Parales and S.M. Resnick
A Genomic Approach to Investigating Baker’s Yeast Reductions; J.D. Stewart
Immobilization of Enzymes as Cross-linked Enzyme Aggregates: A Simple Method for Improving Performance; R.A. Sheldon
Biotechnological Applications of Aldolases; W.D. Fessner and S.Jennewein
Enzymatic Synthesis of Modified Nucleosides; L.A. Condezo, J. Fernández-Lucas, C.A. García-Burgos, A.R. Alcántara, and J.V. Sinisterra
Biocatalytic Reduction of Carboxylic Acids: Mechanism and Applications; P. Venkitasubramanian, L. Daniels, and J.P.N. Rosazza
Dehalogenases in Biodegradation and Biocatalysis; D.B. Janssen
Enzymatic Synthesis of Sugar Esters and Oligosaccharides from Renewable Resources; A. Ballesteros, F.J. Plou, M. Alcalde, M. Ferrer, H. García-Arellano, D. Reyes-Duarte, and I. Ghazi
Efficient Methods and Instrumentation for Engineering Custom Enzymes; S.J. Robles, W.J. Coleman, and M.M. Yang
Deaminating Enzymes of the Purine Cycle as Biocatalysts for Chemoenzymatic Synthesis and Transformation of Antiviral Agents Structurally Related to Purine Nucleosides; E. Santaniello, P. Ciuffreda, and L. Alessandrini
Microbial and Enzymatic Processes for the Production of Chiral Compounds; K. Honda, T. Ishige, and S. Shimizu
Discovery of Arylmalonate Decarboxylase and Conversion of the Function by Rational Design; K. Miyamoto and H. Ohta
Chemoenzymatic Preparation of Enantiopure Building Blocks of Synthetic Utility; K. Mori
Stereoselective Modifications of Polyhydroxylated Steroids; E. Fossati and S. Riva
Recent Developments in Enzymatic Acyloin Condensations; O. Ward and A. Singh
Synthesis of Chiral Alcohols with Carbonyl Reductase Library and Robust NAD(P)H Regenerating System; H. Yamamoto and A. Matsuyama
Comparative Analysis of Chemical and Biocatalytic Syntheses of Drug Intermediates; M.J. Homann, W.C. Suen, N. Zhang, and A. Zaks
Industrial Processes Using Lyases for C–C, C–N, and C–O Bond Formation; M. Pohl and A. Liese
State of the Art and Applications in Stereoselective Synthesis of Chiral Cyanohydrins; F. Effenberger, S. Förster, and C. Kobler
Chiral Switches: Problems, Strategies, Opportunities, and Experiences; R. Csuk
Enzyme Evolution for Chemical Process Applications; G.W. Huisman and J.J. Lalonde
Biocatalytic Routes to Nonracemic Chiral Amines; N.J. Turner and R. Carr
Enantioselective Biocatalytic Reduction of Ketones for the Synthesis of Optically Active Alcohols; S. Buchholz and H. Gröger
Enzyme Catalysis in Nonaqueous Media: Past, Present, and Future;
S. Dreyer, J. Lembrecht, J. Schumacher, and U. Kragl
Biocatalytic Concepts for the Synthesis of Optically Active Amines; S. Buchholz and H. Gröger
Index
Editorial Reviews
“… examines the use of catalysts to produce fine chemicals and chiral intermediates in a variety of pharmaceutical, agrochemical, and other biotechnological applications. The authors analyze the synthesis of chiral intermediates for over 60 brand-name pharmaceuticals for a wide range of drug therapies and treatments. From starting material to product, the chapters offer detailed mechanisms that show chiral intermediates and other by-products for each reaction …”
— In Anticancer Research, Vol. 27, No. 3B, May/June 2007
“This mammoth multi-author volume contains 34 chapters on all aspects of biocatalysis …. In fact the volume covers all the major areas one would wish to see in such a tome and contains some excellent reviews of individual topics.
“…I enjoyed the individual chapters and each author has made an attempt to give an idea of the future perspectives in his area. The chapters are extremely well referenced…”
“There is no doubt that this work should be in the libraries of all who have interests in biocatalysis, whether in academia or in industry … [and] provides relatively up-to-date data on a very wide range of topics in a highly readable format. Recommended…”
—Organic Process Research and Development, Vol. 11, No. 2, p. 296
