Methods in Inhalation Toxicology

Series:
Methods in Life Sciences - Toxicology Section
Published:
November 06, 1996 by CRC Press - 176 Pages
Author(s):
Robert F. Phalen, University of California at Irvine, USA

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Paperback
$179.95
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ISBN 9780849333439
Cat# 3343
 

Features

  • Chapters written by a multidisciplinary, experienced, and active inhalation toxicology research team
  • Coverage from the design of inhalation studies to the post-exposure biological assessments
  • Successfully used designs for air purification systems
  • Important tips on protecting the health of the animal subjects
  • Extensive lists and addresses of suppliers of useful equipment and materials relevant to each major aspect involved with inhalation studies
  • A lay-flat, plastic comb binding for ease of use in the laboratory

    • Summary

    Conducting studies of natural and man-made air contaminants is a specialized research activity that draws upon skills from a variety of disciplines including toxicology, pharmacology, industrial hygiene, and environmental health. Methods in Inhalation Toxicology describes how knowledge from these disciplines is integrated into the design and conduct of inhalation studies. Each of the vital aspects of conducting these studies is discussed in detail, including the use of animal subjects and the related quality control and ethical considerations, air purification methodology, exposure atmosphere generation and characterization, inhalation exposure systems, and real-time and post-exposure biological assessments. These methods will enable you to conduct inhalation studies, easily adding any specific measures of particular interest to your research.
    The book covers techniques needed to:

  • provide suitable clean air for experiments
  • correctly generate the particles and gases being studied
  • select the proper exposure system
  • monitor the exposure
  • prepare tissues for study
  • ensure that animals do not have confounding lung disease
    The helpful descriptions and detailed lists of suppliers of preferred equipment and materials will help you to perform valid, reproducible inhalation toxicology studies. Methods in Inhalation Toxicology is a perfect textbook for students in toxicology programs, as well as for scientists who conduct inhalation studies in both academic and industrial environments.

    • Table of Contents

    Introduction, R.F. Phalen
    Animal Quality and Protocol Approval, W.J. Mautz and M.T. Kleinman
    Cleaning the Air, R.F. Phalen
    Exposure Atmosphere Generation and Characterization, M.T. Kleinman and R.F. Phalen
    Inhalation Exposure Methods, R.F. Phalen
    Animal Monitoring, W.J. Mautz
    Tissue Acquisition and Processing, R. Rasmussen
    Specialized Sampling Techniques, D.K. Bhalla
    Index

    Editorial Reviews

    [The authors] have written a clearly delineated introduction, appropriate for graduate students beginning a career in laboratory-based inhalation toxicology, but equally useful for seasoned investigators whose work leads them into one or more aspects of the field."
    -Journal of Aerosol Medicine

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