Biomedical Imaging in Experimental Neuroscience

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ISBN 9780849301223
Cat# 0335



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  • "Presents a detailed review of the application of biomedical imaging techniques available for noninvasive laboratory animal research
  • "Emphasizes the versatility of MRI in experimental neuroscience research - from anatomy to function
  • "Provides concise, theoretical descriptions of physics with the biologist in mind
  • "Serves as a practical guide with focus on application and implementation
  • Summary

    Recent years have seen an explosion of activity in the field of biomedical imaging in an attempt to understand the behavior of the brain in healthy and disease states. With the emergence of genetically manipulated laboratory mice and the knowledge of the mouse genome, we are entering an exciting new era with revolutionary tools for experimental research. Noninvasive imaging techniques capable of providing both anatomical and functional descriptions of the brain have become essential. Among the various imaging methodologies, magnetic resonance imaging (MRI) stands in the forefront by virtue of its contrast versatility and pathophysiological specificity.

    Emphasizing the relationship between physiological microenvironment and macroscopic imaging signal changes, Biomedical Imaging in Experimental Neuroscience presents a comprehensive review of the noninvasive biomedical imaging techniques available for laboratory animal research. Focusing on MRI, but recognizing the multiple forms of imaging information, this book outlines the scope and limitations of these methods and analyzes their impact on in vivo neuroscience research. The book is intended for the biologist who may not have a background in the physical sciences. This applied guide also provides a concise theoretical description of the pertinent physics.

    Noninvasive imaging offers the obvious benefits of reducing sample sizes and identifying new and unanticipated behaviors. Biomedical Imaging in Experimental Neuroscience presents detailed information for biologists interested in how biomedical imaging may augment their in vivo research and for clinical practitioners seeking deeper insights into the association between imaging findings and disease pathophysiology.

    Table of Contents

    Principles of MRI Contrast, Tim Roberts and Nick van Bruggen

    MRI Measurement of Cerebral Perfusion and Application to Experimental Neuroscience, Mark F. Lythgoe, D.L.Thomas, and F. Calamante

    MRI Measurement of Cerebral Water Diffusion and Its Application to Experimental Research, Richard A. D. Carano, Nick van Bruggen and Alex J. de Crespigny

    Functional Magnetic Resonance Imaging, Mathias Höehn.

    Functional Imaging in Nonhuman Primates, Elizabeth Disbrow

    Pharmacologic Magnetic Resonance Imaging (phMRI), Bruce G. Jenkins, Yin-Ching Iris Chen, and Joseph B. Mandeville

    Anatomical Studies in the Rodent Brain and Spinal Cord: Applications of Magnetic Resonance Microscopy, Helene Benveniste, Tom Mareci, and Steve Blackband

    Magnetic Resonance Spectroscopy: Principles and Applications, Stephen R. Williams and Nicola R. Sibson.

    Small Animal Imaging with Positron Emission Tomography, Simon Cherry and Harley Kornblum

    MRI and Novel Contrast Agents for Molecular Imaging, Michel M. Modo and Steven C.R. Williams

    The Future for Biomedical Imaging: Emerging and Alternative Technologies, Nick van Bruggen and Tim Roberts

    Editorial Reviews

    "…a comprehensive and compelling presentation of the experience and insights of respected experts in the arena of the rapidly evolving neuroimaging techniques and touches on the latest multidisciplinary advances in neuroscience research. … The chapters contributed in this book are written by the absolute best in the field of experimental neuroimaging and cover both modern computational techniques and theoretical considerations but also detail cutting edge methodology, applications, and important "how to's" and imaging protocol details. … highly recommended for not only the student interested in the dynamic changes underway of experimental MRI and molecular imaging but also for the expert already in the field. … Simply put, there is no recent book that covers this highly dynamic field of biomedical imaging in experimental neuroscience with greater depth and insight. It distills the vast amounts of current literature into a highly readable reference that should serve as an ideal introduction to experimental MR, as well as provide the ideal potential textbook to the existing state-of-the-art in MRI and molecular imaging."

    - Michael Moseley, Ph.D.
    Department of Radiology
    Stanford University