Includes a wide range of new concepts, modern technology, and new models for investigating the basis for neuronal injury

Presents new methods and therapeutic approaches for neuronal protection against acute and chronic ischemic episodes

Addresses both basic and clinical issues regarding the future of ischemia research

Describes new animal models for ischemia research including the application of transgenic animals and stem cells transplantation

Approximately half a million Americans suffer brain ischemic episodes every year. These brain strokes are the third leading cause of death in the United States and the number-one cause of permanent disability. Over the past decade, we have made extensive attempts to understand the biological mechanisms that underlie stroke-induced neuronal injury. This research has been benefited by the introduction of a variety of new technologies and assays aimed at deciphering the complex neuronal degenerating processes triggered by cerebral vascular disorders or other neurological diseases that produce ischemic episodes.

New Concepts in Cerebral Ischemia presents techniques and theories for understanding the various stages of early pathogenesis in order to design specific strategies to protect neurons from further injury. Short, specific, and comprehensive chapters provide detailed descriptions of the new methods employed in both basic and clinical research that are revolutionizing the field of ischemia research. Written by international experts in CNS dysfunction, the book includes methods to elucidate the pathogenesis of ischemia, technologies used in the design of specific strategies to protect neurons from further injury, and new approaches to treat patients with acute ischemic episodes. With this book, you will gain new insights not only into cerebral vascular research, but also into neurological disease in general.

Gender Differences in Post-Ischemic and Post-Traumatic Brain Injury, Robin L. Roof and Edward D. Hall

Neonatal Hypoxic-Ischemic Insults and Their Mechanism, Michael V. Johnston

Neural Stem Cell Biology Provides Insights into New Therapeutic Strategies for Hypoxic-Ischemic Brain-Injury, Kook In Park and Evan Y. Snyder

Cellular and Molecular Mechanisms of Ischemic Tolerance, Kimberly L. Simpson and Rick C.S. Lin

Excitotoxicity, Oxidative Stress, and Apoptosis in Ischemic Neuronal Death, B.J. Gwag, Seok Joon Won, and Doo Yeon Kim

Immediate and delayed Factors Causing Neuronal Death after Ischemic and Excitotoxic Insults, John A. Connor and S.W.R. Shuttleworth

Mechanism of Zinc-Induced Neuronal Death, Jae-Young Koh, Yang-Hee Kim, Jeong Ae Park, and Joo-Yong Lee

Cerebral Ischemia and Adenosine, Dag K.J.E. von Lubitz
Calpain and Caspase in Ischemic and Traumatic Brain Injury, Kevin W. Wang

The Potential Role of Hyperbaric Oxygen Therapy as an Adjunctive Treatment Modality for Stroke, Eric J. Zoog

Brain Inflammation, Cytokines, and p38AP Kinase Signaling in Stroke, Frank C. Barone, Ronald F. Tuma, Jeffrey J. Legos, Joseph A. Erhardt, and Andrew A. Parsons