Liquid Chromatography-Mass Spectrometry, Third Edition
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Summary
A constructive evaluation of the most significant developments in liquid chromatography–mass spectrometry (LC–MS) and its uses for quantitative bioanalysis and characterization for a diverse range of disciplines, Liquid Chromatography–Mass Spectrometry, Third Edition offers a well-rounded coverage of the latest technological developments and applications.
As the technology itself has matured into a reliable analytical method over the last 15 years, the most exciting developments occur in LC–MS augments research into new applications. This edition places a stronger emphasis than previous editions on the impact of LC–MS methods, dedicating two-thirds of the text to small-molecule and biomolecular applications such as proteomics, pharmaceutical drug discovery and development, biochemistry, clinical analysis, environmental studies, and natural products research. Supported by the most relevant literature available, each chapter examines how the strategies, technologies, and recent advances—from sample pretreatment to data processing—in LC–MS helped to shape these disciplines.
Featuring new chapters and extensive revisions throughout the book, Liquid Chromatography–Mass Spectrometry, Third Edition continues to provide scientists with a definitive guide and reference to the most important principles, strategies, and experimental precedents for applying LC–MS to their research.
Table of Contents
INTRODUCTION
Liquid Chromatography and Sample Pretreatment
Mass Spectrometry
TECHNOLOGY
Strategies in LC–MS Interfacing
History of LC–MS Interfaces
Interfaces for Atmospheric-Pressure Ionization
Atmospheric-Pressure Ionization
APPLICATIONS: SMALL MOLECULES
LC–MS Analysis of Pesticides
Environmental Applications of LC–MS
LC–MS in Drug Discovery and Development
LC–MS in Drug Metabolism
Quantitative Bioanalysis Using LC–MS
Clinical Applications of LC–MS
LC–MS Analysis of Steroids
LC–MS in Food Safety Analysis
LC–MS Analysis of Plant Phenols
APPLICATIONS: BIOMOLECULES
LC–MS analysis of Proteins
LC–MS analysis of Peptides / Enabling Technology
LC–MS in Proteomics
LC–MS for Identification of Post-Translational Modifications
LC–MS Analysis of Oligosaccharides
LC–MS Analysis of Lipids and Phospholipids
LC–MS Analysis of Nucleic Acids INDEX
Editorial Reviews
"This book offers a well-rounded coverage of the latest technological developments and applications … "
—Anticancer Research, October 2008
“… this book covers a variety of topics that are of interest to practitioners of LC-MS. The 22 chapters cover multiple topics and include practical tips as well as a useful list of references for the reader who wants to learn more about the particular topic. This book can be used as a reference book by both scientists with years of LC-MS experience as well as those scientists who are just beginning to utilize this excellent analytical tool.”
— Walter A. Korfmacher, Exploratory Drug Metabolism, Schering-Plough Research Institute, New Jersey, in American Society for Mass Spectrometry, 2007
”...Features new chapters and extensive revisions. ...Discusses how the technique works and how to interpret results. ...Describes the impact of [LC-MS] on small-molecule and biomolecular applications...”
— Biophotonics International, August 2006
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