An exploration of high-throughput synthesis, this book presents a compilation of how-to methods, novel materials, and catalyst developments for creating a multitude of new compounds. Introductory sections are coupled with in-depth case studies clarifying theory through practice. The book emphasizes the potential for reproducing experiments in detail.
Theory and methods in solid phase organic synthesis: an introduction to solid phase organic synthesis; methods of analysis to determine the progress of a chemical reaction on solid support. High throughput synthesis for drug discovery: high throughput organic synthesis - a perspective looking back on 10 years of combinatorial chemistry; techniques and strategies for producing compound libraries for biological screening; high throughput purification strategies; automating high throughput organic synthesis. High throughput synthesis of new materials and catalysts: synthesis and high throughput evaluation of complex functional materials chips; high throughput screening of catalyst libraries. New directions in high throughput synthesis: microfluidic analysis, screening and synthesis; sensors; the use of magnetic separation coupled with power ultrasound for high throughput solid phase organic synthesis.
"From the foreword. . . . . .This book will certainly contribute to...more successful application[s of combinatorial chemistry]. It was an excellent idea to write the book in the present cookbook format. Listing of the chemicals and equipment used in the syntheses and descriptions of the procedures and even the postsynthetic analyses. . .will be very useful for the readers and. . .help them to design their own combinatorial experiments. "
---Professor Árpád Furka, Department of Organic Chemistry, Eötvös Lorand University, Budapest, Hungary