This book draws together recent data on both cytoplasmic and flagellar dyneins and the proteins they interact with, to give the reader a clear picture of what is currently known about the structure and mechanics of these remarkable macro-molecular machines. Each chapter is written by active researchers, with a focus on currently used biophysical, biochemical, and cell biological methods. In addition to comprehensive coverage of structural information gained by electron microscopy, electron cryo-tomography, X-ray crystallography, and nuclear magnetic resonance, this book provides detailed descriptions of mechanistic experiments by single-molecule nanometry.
Biomolecular Components of a Biosensor: Fundamentals, Kaustubh D. Bhalerao and Goutam J. Nistala
What Makes a Biosensor a Biosensor?
The Recognition Layer
Bioconjugation
Conclusions and Future Outlook
Macromolecule-Imprinted Polymers: Antibody/Receptor Mimics for Protein Recognition and Catalysis, Yun Peng, David W. Britt, Marie K. Walsh, and Timothy Doyle
Introduction
Applications
Perspective
Chemical and Biological Sensing and Imaging Using Plasmonic Nanoparticles and Nanostructures, Qi Wang and Chenxu Yu
Introduction
Theoretical Background of nanoSPR
Synthesis, Fabrication, and Functionalization of Plasmonic Nanostructures
Application of nanoSPR in Chemical and Biological Sensing
Conclusions and Future Perspectives
Surface-Raman Scattering for Medical Applications, Mustafa Çulha
Introduction
Introduction to Raman Scattering and Surface-Enhanced Raman Scattering
Applications of SERS in Biomedical Sciences and Medicine
Concluding Remarks and Future Outlook
Diagnostic and Therapeutic Applications of Carbon Nanotubes, Balaji Panchapakesan, Thomas Burkhead, Ben King, Peng Xu, James Loomis, and Eric Wickstrom
Introduction
Nanotechnology for Cancer
Carbon Nanotubes
Electronic Properties of Carbon Nanotubes
Optical Properties of Carbon Nanotubes
Biological Applications of Carbon Nanotubes
Bioelectronic Devices Based on Carbon Nanotubes
Applications of Nanotube Transistors for Detecting Circulating Cancer Cells
Integrated Molecular Targeting and Selective Photothermal Therapy of Breast Cancer Cells Using Carbon Nanotubes
Conclusions and Future Applications of Carbon Nanotubes for Biomedical
Graphene for Biosensing Applications, Romaneh Jalilian, Luis A. Jauregui, Kyuwan Lee, Yong P. Chen, and Joseph Irudayaraj
Introduction
Fabrication of Graphene-Based Materials and Devices
Basic Properties of Graphene
Biosensing Applications of Graphene
Closing Remarks and Future Work
Single-Molecule Fluorescence Spectroscopy Techniques for Biomedicine, Jose M. Moran-Mirabal, Harold G. Craighead, and Larry P. Walker
Single-Molecule Fluorescence Spectroscopy Fundamentals
Experimental Implementations of SMFS Techniques
Observables Measured with SMFS Techniques
Micro- and Nanostructured Surfaces for SMFS
Micro- and Nanofluidic Slits and Channels
Potential Biomedical SMFS Applications
Particle Engineering for Inhalational Drug Delivery, Basma Ibrahim, Yan Yang, and Yoon Yeo
Dry Particles for Inhalational Therapy
Traditional Particle Manufacturing for Inhalational Drug Delivery
NPs for Inhalational Drug Delivery
Conclusions
Devices and Sensors for Bioelectric Monitoringand Stimulation, Benjamin Moody, Mathew K. Zachek, and Gregory S. McCarty
Introduction
Electrode Basics
Electrochemical Measurements
Biosensor Electrodes
Advances in Electrodes for Biological Measurements
Applications in the Brain
Applications to the Heart and Muscles
Conclusion
Microelectromechanical Systems for in vivo Therapeutics, Masaru P. Rao
Introduction
Advantageous Features of MEMS
The MEMS "Tool Kit": Common MEMS Materials and Fabrication Techniques
Selected Examples of Application Areas within in vivo Therapeutics
In vivo Therapeutic MEMS Enabled by Titanium Micromachining
Conclusions and Outlook
Implantable Electrochemical Biosensors: A Perspective, Sridhar Govindarajan and Bella B. Manshian
Introduction
In vivo Monitoring — Challenges and Progress
Conclusions
Index
Biography
Joseph M. Irudayaraj
"Biomedical nanosensors have a wide range of applications in human, animal, and plant health for diagnostics and therapeutics. Assembled by Prof. Joseph Irudayaraj, this book is an important reference in the exciting, important, and rapidly evolving field of biomedical nanotechnology. The chapters are detailed and thorough, and rich with references. It is an interdisciplinary collection of contributions from experts with diverse backgrounds, and therefore a very interesting and educational read for students and faculty researchers in bionanotechnology."
—Prof. Rashid Bashir - University of Illinois at Urbana-Champaign, USA"This book gives an inspirational overview on current developments in nanomaterial and nanoarchitecture for advanced sensing applications in the fields of medical diagnostics and therapeutics agents for drug delivery. It focuses on the nanoscale perspective of materials properties towards new sensing strategies to study the biological systems with improved sensitivity, to characterize molecular interaction and cellular mechanisms at molecular or cellular dimension. The content is comprehensive and rich in references covering the topics on fundamental biosensor design, natural and synthetic biorecognition elements, inorganic nanomaterials such as gold nanoparticles and carbon nanotube-based sensors, engineered nanoparticles for drug delivery, and nanoarchitecture and nanodevices towards implantable sensing. Each chapter is provided with a clear and brief introduction, the sub-topics are well organized and easy to follow, and summarized with a prospective and future outlook. . . .
I am very impressed by the concise and informative content of this . . . very useful reference work for research scientists working in the field of nanotechnology, as well as high school teachers and university students to get an overview on the topic of biomedical nanosensors."
—Dr. W. C. Mak, Biosensors and Bioelectronics Centre, Department of Physics, Chemistry and Biology, Linköping University, Sweden
