1st Edition

Chemical Processes with Participation of Biological and Related Compounds Biophysical and Chemical Aspects of Porphyrins, Pigments, Drugs, Biodegradable Polymers and Nanofibers

By Lomova, Gennady Zaikov Copyright 2008

    The book is devoted to kinetics and thermodynamics of the processes with participation of some biological compounds and their synthetic analogues. Aspects of their acting as model enzymes, molecular receptors, photo sensitizers, pharmocophores, and biopharmaceutical compounds are under consideration. Quantitative characteristics of transfer of cations, anions and small organic molecules, fermentative catalysis, diffusion of the drug molecular through biological membranes are found. Mechanisms of the processes are discussed. Biological activity of studied compounds is evaluated. Bio-damages of materials as well as adhesions of microorganisms on materials surface are investigated.

    Preface
    Foreword

    Synthetic and Natural Bacteriochlorins: Synthesis, Properties and Applications M.A. Grin and A.F. Mironov
    Introduction
    Synthetic bacteriochlorins
    Natural bacteriochlorins and their chemical modifications
    Amphiphilic and water-soluble derivatives of bacteriochlorins
    Conclusion
    References
    meso
    -Phenylporphyrins as Synthetic Models of Natural Porphyrins: Synthesis and Modification
    A.S. Semeykin, S.A. Syrbu and O.I. Koifman
    Introduction
    Synthesis of meso(5,10,15,20)-tetrasubstituted porphyrins
    meso(5,15)-Disubstituted porphyrins
    Synthesis of meso(5)-Phenyl-b-octaalkylporphyrins
    Reactions of introduction and modification of substituents in phenyl rings of meso-phenyl-substituted porphyrins
    References
    The Mechanism of Catalytic Action of the Coordination Centres of Catalase Synthetic Models T.N. Lomova, M.E. Klyueva and M.V. Klyuev
    Introduction
    Substituted copper(II) porphyrins as catalysts of the hydrogen peroxide disproportionation reaction
    Kinetic regularities and mechanisms of peroxide decomposition reactions in the presence of acido complexes of highly substituted manganese porphyrins
    Conclusion
    References
    Complexation of Porphyrins with Ions and Organic Molecules N.Zh. Mamardashvili, V.V. Borovkov, G.M. Mamardashvili, Y. Inoue and O.I. Koifman
    Introduction
    Complexation of porphyrins with ions
    Complexation of porphyrins with organic molecules: the thermodynamic aspect
    Complexation of porphyrins with organic molecules: the chirality aspect
    Conclusion
    References
    Chemical Activation of Porphyrins in Coordination Core Reactions D.B. Berezin and B.D. Berezin
    Introduction
    Porphyrin ligands with localized and delocalized NH bonds
    Reactivity of the coordination core in molecules of porphyrin ligands
    Biosignificance of the phenomenon of NH activation
    References
    Synthesis, Structure Peculiarities and Biological Properties of Macroheterocyclic Compounds M.K. Islyaikin, E.A. Danilova, Yu.V. Romanenko, O.G. Khelevina and T.N. Lomova
    Introduction
    Synthesis, structure and properties of the initial compounds
    ABBB-type macroheterocyclic compounds
    Azolophthalocyanines
    State of triazoleporphyrazines in proton-donor media
    ABAB-type macroheterocyclic compounds
    ABABAB-type macroheterocyclic compounds
    Coordination properties
    Studies of the practically valuable properties of macroheterocyclic compounds and their metal complexes
    References
    The Photochemical Aspect of Reactions of Flavonols with Molecular Oxygen
    E.A. Venedictov
    Introduction
    Structure of flavonols
    Spectral luminescent properties of flavonols
    Photoproduction of 1O2 (1g)
    1O2 Reactions
    Photochemical properties of coordination compounds of quercetine
    Conclusion
    References
    Solvation of Drugs as a Key for Understanding Partitioning and Passive Transport Exemplified by NSAIDs German L. Perlovich and Annette Bauer-Brandl
    Introduction
    Partitioning and diffusion
    Solvation of drugs: relevance and theoretical approaches
    Experimental methods to measure solvation characteristics and choice of subjects
    Crystal structures of NSAIDs
    Thermochemical and thermodynamic properties of NSAIDs
    The difference between partitioning and distribution of NSAIDs from the thermodynamic point of view
    Correlation between biopharmaceutically relevant parameters and solvation characteristics
    References
    Biodamage of Materials: Adhesion of Microorganisms on the Surface of Materials K.Z. Gumargalieva, I.G. Kalinina, S.A. Semenov and G.E. Zaikov
    Introduction
    Results and discussion
    References
    Controlled Release of Aseptic Drug from Poly(3-hydroxybutyrate) Films: A Combination of Diffusion and Zero-order Kinetics
    R.Y. Kosenko, Y.N. Pankova, A.L. Iordanskii, A.P. Bonartsev, and G.E. Zaikov
    Introduction
    Experimental
    Results and discussion
    Conclusion
    Acknowledgement
    References
    Transport of Water as a Structurally Sensitive Process Characterizing the Morphology of Biodegradable Polymer Systems
    A.L. Iordanskii, Yu.N. Pankova, R.Yu. Kosenko, A.A. Ol’khov and G.E. Zaikov
    Introduction
    Experimental
    Hydrophobization of poly-(3-hydroxybutyrate)
    Hydrophilization of poly-(3-hydroxybutyrate)
    References
    A Novel Technique for Measurement of Electrospun Nanofiber M. Ziabari, V. Mottaghitalab and A.K. Haghi
    Introduction
    Methodology
    Experimental
    Results and discussion
    Conclusion
    References
    Image Analysis of Pore Size Distribution in Electrospun Nanofiber Webs: New Trends and Developments
    M. Ziabari, V. Mottaghitalab and A.K. Haghi
    Introduction
    Methodology
    Experimental
    Results and discussion
    Conclusion
    References
    Electrospun Biodegradable and Biocompatible Natural Nanofibers: A Detailed Review
    A.K. Haghi and R.K. Haghi
    Introduction
    Effect of systematic parameters on electrospun nanofibers
    Theory and modeling
    Natural fibers
    Electrospinning of silk fibers
    Electrospinning of cellulose and cellulose acetate
    Concluding remarks
    References
    Nomenclature

    Biography

    Lomova\, ; Zaikov\, Gennady