1st Edition
Wheezing Disorders in the Pre-School Child Pathogenesis and Management
The infant with persistent or recurrent wheeze during the first 2 years of life poses a particularly difficult diagnostic dilemma, which can be a source of considerable anxiety to both physicians and parents. Without neglecting basic science, Wheezing Disorders in the Preschool Child presents information in a logical and readable fashion that is particularly useful to the practicing clinicians. Simon Godfrey and Fernando Martinez, two internationally respected opinion leaders in the field of respiratory disorders in childhood, provide a comprehensive overview of the diagnosis and management of paediatric asthma.
Focusing on practical issues, the authors expose the lack of existing data on the etiology and pathophysiology of the disease process, outline the optimal approach to diagnosis and management, and discuss the importance of early wheezing as a predictor of the future development of chronic respiratory symptoms in later life. They discuss a simple, logical, and safe approach to management bases on trial and error, that ensures that patients do not continue to receive treatment that is ineffective. The book blends the latest information with practical experience.
EPIDEMIOLOGY OF WHEEZING IN INFANTS AND PRESCHOOL CHILDREN
Incidence of First Episodes of Wheezing
Infection as a Factor in the Etiology of Wheezing
Recurrence of Wheezing and its Causes
What Becomes of the Wheezy Infant and Preschool Child?
RESPIRATORY SYNCYTIAL VIRUS (RSV) INFECTION AND WHEEZING
Introduction
Clinical Presentations
Diagnosis
Epidemiology
Genetics
Treatment
Prevention
IMMUNOLOGY OF WHEEZING DISORDERS IN INFANTS AND PRESCHOOL CHILDREN
Immunology of Wheezing Not Related to Atopy
Immunology of Atopic Wheezing
Towards a Unified Theory of the Beginnings of Wheezing Disorders
Immunology of Wheezing at the Beginnings of Life: A Comprehensive View
CLINICAL FEATURES OF THE WHEEZY INFANT
Introduction
How Well Do Parents Recognize Wheezing in Their Children
Clinical Features of the Typical Wheezy Infant and Preschool Child
Management Decisions
Clinical Features of the Atypical Wheezy Infant and Preschool Child
LUNG FUNCTION IN THE WHEEZY INFANT AND PRESCHOOL CHILD
Basic Pulmonary Physiology Relevant to Disorders Associated with Wheezing
How are Tests of Lung Function Used Clinically in Older Subjects with Obstructive Lung Disease?
Lung Function Tests for the Very Young
Lung Function in the Typical Wheezy Infant
Bronchial Responsiveness in the Typical Wheezy Infant
Prognosis of Altered Lung Function in the Typical Wheezy Infant
Lung Infection in the Atypical Wheezy Infant
Bronchial Hyperresponsiveness in the Preschool Child
Is There a Place for Tests of Lung Function in the Wheezy Infant?
THE WHEEZY INFANT AND PRESCHOOL CHILD: DIFFERENTIAL DIAGNOSIS
Introduction
Important Conditions Which May Present as Atypical Wheezing
What Should Arouse Suspicion of an Atypical Cause of Wheezing?
When Suspicion of Atypical Wheezing is Aroused What Tools are Available to Help with Diagnosis?
Conclusions
MANAGEMENT OF WHEEZING IN INFANTS AND PRESCHOOL CHILDREN
Introduction
First Time Wheezing in Early Infancy
Recurrent Wheezing in Infancy and Early Childhood
Making the Correct Diagnosis of Recurrent Wheezing
Evaluation of Severity of Wheezing Attacks
Management Plan for the Wheezy Infant and Preschool Child
Medications Used in the Management Plan for the Wheezy Infant and Preschool Child
Delivery Devices for Inhalation Suitable for Infants and Young Children
Treating the Wheezy Infant of Preschool Child Who Does not Respond to Medication
Effect of Treatment on Long-Term Prognosis
PROPOSALS FOR THE FUTURE
Introduction
Studies to Establish the Relationship Between Genetic Predisposition, Environmental Exposure, and the Various Types of Typical Wheezing in Infancy and Early Childhood
Studies of the Genetics, Risk Factors for and the Treatment of Acute Bronchiolotis due to Respiratory Syncytial Virus (RSV)
Studies of the Immunologic Basis of Wheezing Diseases of Infancy and Early Childhood
Studies of the Clinical and Functional Evaluation of the Typical Wheezy Infant and Preschool Child
Studies of the Prevention and Treatment of the Typical Wheezy Infant and Preschool Child
Biography
Fernando D. Martinez and Simon Godfrey
"...successfully melds a state of the art review of the subject with practical guidance to aid clinicians dealing with the wheezing infant. I enjoyed reading it and would recommend it to all my colleagues." - Pediatric Allergy & Immunology
