1st Edition

TNF Superfamily

By Sanjay V. Khare Copyright 2007
    100 Pages 9 B/W Illustrations
    by CRC Press

    The tumor necrosis factor/receptor [TNF/TNFR] superfamily consists of more than 20 transmembrane proteins with conserved N-terminal cysteine-rich domains [CRDs] in the extracellular ligand binding region. Members have wide tissue distribution and play important roles in biological processes such as lymphoid and neuronal development, innate and adaptive immune response, and cellular homeostasis. The chapters of this book address some of the most interesting functions of the TNF/TNFR superfamily.

    Preface 1. CD40 and CD154 2. Regulation of T Cell Immunity by 0X40 and OX40L 3. Signal Transduction in Osteoclast Biology: The OPG-RANKL-RANK Pathway 4. Tumor Necrosis Factor (TNF) and Neurodegeneration 5. The Role of LIGHT in Autoimmunity 6. CD 137 Pathway in Innate and Adaptive Immunity

    Biography

    Sanjay V. Khare, Amgen Inc. Thousand Oaks, California, U.S.A.