1st Edition

A-Beta Metabolism and Alzheimer's Disease

By Takaomi Comings Saido Copyright 2003

    This book provides information regarding three major aspects of Aβ metabolism: generation from its precursor, degradation within the brain, and transport out of the brain. It is useful for graduate students, post-doctoral fellows, and scientists both in this and other disciplines.

    Beta-secretase M. Citron

    Alpha-secretases S. Ishiura

    ADAM 10/alpha secretase and presenilins/gamma secretase in APP processing and notch signaling D. Hartmann

    Gamma-secretase and presenilin M. Wolfe

    Biochemistry of gamma-secretase (tentative title) S. Sinha

    Presenilin and intracellular protein transport Degradation of Abeta by neprilysin T.C. Saido

    Degradation of Abeta by endothelin-converting enzyme C. Eckman

    Degradation of Abeta by insulin-degrading enzyme Lipid raft and Abeta metabolism T. Golde

    Lipid raft and Abeta accumulation M. Morishima-Kawashima and Y. Ihara

    Transport-dependent clearance of Abeta B. Zlokovic

    Abeta vaccination C. Lemere

    Biography

    Saido, Takaomi Comings