1st Edition

Biological Effects of Low Level Exposures Dose-Response Relationships

By Edward J. Calabrese Copyright 1994
    320 Pages
    by CRC Press

    Biological Effects of Low-Level Exposures, more commonly referred to as BELLE, began as a conference in May 1990. Its members are committed to the enhanced understanding of low-dose responses of all types to human exposures to chemical and physical agents, whether of an expected or paradoxical nature.
    The focus of BELLE encompasses dose-response relationships to toxic agents, pharmaceuticals, and natural products over wide dosage ranges in both in vitro systems and in vivo systems, including human populations. While BELLE promotes the scientific understanding of low-level effects, its primary goal is the scientific evaluation of existing literature and ways to improve research and assessment methods.

    Historical, Philosophical, Conceptual Foundations of BELLE Research
    Changing Scientific Paradigms, K.F. Schaffner
    A Brief History and Critique of the Low Dose Effects Paradigm, L. Sagan
    Primer on BELLE, E.J. Calabrese
    Commentary on Changing Paradigms: Consistencies and Inconsistencies of Changes in Molecular to Biological Events During Malignant Progression in Transformed Human Cells, G.E. Milo
    Biological Effects of Low Level Exposure to Chemicals
    Nonmonotonic Dose-Response Relationships in Toxicological Studies, J.M. Davis and D.J. Svendsgaard
    Biostatistical Approaches to Low Level Exposures, D.W. Gaylor
    Responses in Humans to Low Level Exposures, R.R. Cook
    Cellular and Molecular Foundations of Hormetic Mechanisms, H.M. Mehendale
    Modulation of Toxicity by Diet: Implications for Response at Low Level Exposures, A. Turutrro and R. Hart
    Biological Effects of Low Level Exposure to Radiation
    What Can be Learned from Epidemiologic Studies of Persons Exposed to Low Doses of Radiation? E.S. Gilbert
    Positive Health Effects of Low Level Radiation in Human Populations, M. Pollycove
    Test of the Linear-No Threshold Theory of Radiation Carcinogenesis, B.L. Cohen
    Bayesian Estimation of Incidence Change-Points in Low Dose Experimental and Epidemiologic Studies, B.A. Carnes
    Radiation-Induced Carcinogenesis: Paradigm Considerations, J.E. Trosko
    Stress Proteins and Radiation, J. Smith-Sonneborn
    Adaptive Responses After Exposure to Low Dose Radiation, C.K. Hill and T. Godfrey
    BELLE Conference Perspectives and Summary
    Synopsis of the BELLE Conference on Chemicals and Radiation, J.D. Graham
    New Perspectives on Dose-Response Relationships and Low Level Exposures, J. Higginson
    BELLE Conference: A Summary, L. Sagan
    Appendix: What is BELLE? Where is BELLE and Who Sponsors It?
    List of Acronyms and Abbreviations
    List of Contributors
    Index

    Biography

    Edward J. Calabrese